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Keywords = tumor necrosis factor α-inducing protein 8 (TNFAIP8)

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16 pages, 32653 KiB  
Review
Oncogenic Role of Tumor Necrosis Factor α-Induced Protein 8 (TNFAIP8)
by Suryakant Niture, Xialan Dong, Elena Arthur, Uchechukwu Chimeh, Samiksha S. Niture, Weifan Zheng and Deepak Kumar
Cells 2019, 8(1), 9; https://doi.org/10.3390/cells8010009 - 24 Dec 2018
Cited by 62 | Viewed by 8986
Abstract
Tumor necrosis factor (TNF)-α-induced protein 8 (TNFAIP8) is a founding member of the TIPE family, which also includes TNFAIP8-like 1 (TIPE1), TNFAIP8-like 2 (TIPE2), and TNFAIP8-like 3 (TIPE3) proteins. Expression of TNFAIP8 is strongly associated with the development of various cancers including cancer [...] Read more.
Tumor necrosis factor (TNF)-α-induced protein 8 (TNFAIP8) is a founding member of the TIPE family, which also includes TNFAIP8-like 1 (TIPE1), TNFAIP8-like 2 (TIPE2), and TNFAIP8-like 3 (TIPE3) proteins. Expression of TNFAIP8 is strongly associated with the development of various cancers including cancer of the prostate, liver, lung, breast, colon, esophagus, ovary, cervix, pancreas, and others. In human cancers, TNFAIP8 promotes cell proliferation, invasion, metastasis, drug resistance, autophagy, and tumorigenesis by inhibition of cell apoptosis. In order to better understand the molecular aspects, biological functions, and potential roles of TNFAIP8 in carcinogenesis, in this review, we focused on the expression, regulation, structural aspects, modifications/interactions, and oncogenic role of TNFAIP8 proteins in human cancers. Full article
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19 pages, 977 KiB  
Review
TIPE Family of Proteins and Its Implications in Different Chronic Diseases
by Devivasha Bordoloi, Kishore Banik, Bano Shabnam, Ganesan Padmavathi, Javadi Monisha, Frank Arfuso, Arunasalam Dharmarajan, Xinliang Mao, Lina H. K. Lim, Lingzhi Wang, Lu Fan, Kam Man Hui, Alan Prem Kumar, Gautam Sethi and Ajaikumar B. Kunnumakkara
Int. J. Mol. Sci. 2018, 19(10), 2974; https://doi.org/10.3390/ijms19102974 - 29 Sep 2018
Cited by 70 | Viewed by 7358
Abstract
The tumor necrosis factor-α-induced protein 8-like (TIPE/TNFAIP8) family is a recently identified family of proteins that is strongly associated with the regulation of immunity and tumorigenesis. This family is comprised of four members, namely, tumor necrosis factor-α-induced protein 8 (TIPE/TNFAIP8), tumor necrosis factor-α-induced [...] Read more.
The tumor necrosis factor-α-induced protein 8-like (TIPE/TNFAIP8) family is a recently identified family of proteins that is strongly associated with the regulation of immunity and tumorigenesis. This family is comprised of four members, namely, tumor necrosis factor-α-induced protein 8 (TIPE/TNFAIP8), tumor necrosis factor-α-induced protein 8-like 1 (TIPE1/TNFAIP8L1), tumor necrosis factor-α-induced protein 8-like 2 (TIPE2/TNFAIP8L2), and tumor necrosis factor-α-induced protein 8-like 3 (TIPE3/TNFAIP8L3). Although the proteins of this family were initially described as regulators of tumorigenesis, inflammation, and cell death, they are also found to be involved in the regulation of autophagy and the transfer of lipid secondary messengers, besides contributing to immune function and homeostasis. Interestingly, despite the existence of a significant sequence homology among the four members of this family, they are involved in different biological activities and also exhibit remarkable variability of expression. Furthermore, this family of proteins is highly deregulated in different human cancers and various chronic diseases. This review summarizes the vivid role of the TIPE family of proteins and its association with various signaling cascades in diverse chronic diseases. Full article
(This article belongs to the Special Issue Feature Annual Reviews in Molecular Sciences 2019)
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