Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline

Journals

Article Types

Countries / Regions

Search Results (1)

Search Parameters:
Keywords = tripterhyponoid A

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
17 pages, 3567 KiB  
Article
Tripterhyponoid A from Tripterygium hypoglaucum Inhibiting MRSA by Multiple Mechanisms
by Yan-Yan Zhu, Qiong Jin, Zhao-Jie Wang, Mei-Zhen Wei, Wen-Biao Zu, Zhong-Shun Zhou, Bin-Yuan Hu, Yun-Li Zhao, Xu-Jie Qin and Xiao-Dong Luo
Molecules 2025, 30(12), 2539; https://doi.org/10.3390/molecules30122539 - 10 Jun 2025
Viewed by 517
Abstract
The emergence of methicillin-resistant Staphylococcus aureus (MRSA) and its biofilm-forming ability underscore the limitations of current antibiotics. In this study, a new compound named tripterhyponoid A was found to effectively combat MRSA, with an MIC of 2.0 μg/mL. It inhibited biofilm formation by [...] Read more.
The emergence of methicillin-resistant Staphylococcus aureus (MRSA) and its biofilm-forming ability underscore the limitations of current antibiotics. In this study, a new compound named tripterhyponoid A was found to effectively combat MRSA, with an MIC of 2.0 μg/mL. It inhibited biofilm formation by downregulating genes related to the quorum sensing (QS) pathway (sarA, agrA, agrB, agrC, agrD, and hld) and eradicated mature biofilms. Furthermore, it induced DNA damage by binding to bacterial DNA, enhancing its efficiency against MRSA. Therefore, its anti-MRSA properties with multiple mechanisms of action make it less prone to developing resistance over 20 days. In addition, it reduced the bacterial load and regulated the levels of inflammatory cytokines IL-6 and IL-10 at the wound site in a mouse skin infection model. This paper provides the first in-depth investigation of the mechanisms of triterpenoids against MRSA by inhibiting the expression of QS system genes and binding to DNA. Full article
Show Figures

Graphical abstract

Back to TopTop