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Keywords = tetrasubstituted pyrazines

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4 pages, 481 KiB  
Proceeding Paper
Multiple Pathways in Cp2TiCl2—Catalyzed Reaction of Tetraalkyl-Substituted Pyrazines with EtAlCl2 and Mg
by Mariya G. Shaibakova, Nikita A. Rikhter, Leisan K. Dilmukhametova and Ilfir R. Ramazanov
Chem. Proc. 2022, 12(1), 89; https://doi.org/10.3390/ecsoc-26-13709 - 18 Nov 2022
Viewed by 1773
Abstract
There exist a number of classical methods for the synthesis of substituted pyrazines. Among this variety of reactions, the synthesis of substituted pyrazines from nitriles does not stand out in either the number of known examples or in product yield. However, the one-stage [...] Read more.
There exist a number of classical methods for the synthesis of substituted pyrazines. Among this variety of reactions, the synthesis of substituted pyrazines from nitriles does not stand out in either the number of known examples or in product yield. However, the one-stage character of the transformation, together with the uncertainty of its mechanism, aroused our interest in this catalytic reaction. Here, we report the successful implementation of the Cp2TiCl2-catalyzed reaction of aliphatic nitriles with EtAlCl2 and Mg, which led to the selective preparation of 2,3,5,6-tetraalkyl-substituted pyrazines, 2,4,5-trisubstituted-1H-imidazole or 2-aminocyclopent-1-ene-carbonitrile depending on reaction conditions and substituents. Full article
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