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Search Results (3)

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Keywords = sutureless amniotic membrane transplantation

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11 pages, 23013 KiB  
Article
Self-Retained, Sutureless Amniotic Membrane Transplantation for the Management of Ocular Surface Diseases
by Hsun-I Chiu and Chieh-Chih Tsai
J. Clin. Med. 2023, 12(19), 6222; https://doi.org/10.3390/jcm12196222 - 27 Sep 2023
Cited by 6 | Viewed by 2185
Abstract
Amniotic membrane (AM) has anti-inflammation, anti-fibrotic, and regenerative effects. Sutureless cryopreserved AM transplantation, ProKera® (Bio-Tissue, Inc., Miami, FL, USA), is easily applied by ophthalmologists in the treatment of ocular surface diseases. This retrospective study included patients with ocular surface diseases who received [...] Read more.
Amniotic membrane (AM) has anti-inflammation, anti-fibrotic, and regenerative effects. Sutureless cryopreserved AM transplantation, ProKera® (Bio-Tissue, Inc., Miami, FL, USA), is easily applied by ophthalmologists in the treatment of ocular surface diseases. This retrospective study included patients with ocular surface diseases who received ProKera® between January 2022 and May 2023. Six patients (9 eyes) with a mean age of 56.8 ± 20.8 years old (range 25–74) and a mean follow-up period of 7.8 ± 4.1 months (range 1–12) were included, including 2 of recurrent conjunctival tumors with limbal and corneal involvement (cases 1–2), 1 of pterygium with marked astigmatism (case 3) and 3 of Stevens–Johnson syndrome (SJS, cases 4–6). ProKera® was inserted after the lesion excision and deep keratectomy in cases 1–3, and no recurrence or corneal complication was noted. Cases 4–5 were discharged from the intensive care unit and presented with severe chronic SJS. Most ocular manifestations improved significantly after symblepharon release and ProKera® insertion, except for corneal conjunctivalization in 1 eye (case 5). Case 6 involved early ProKera® use at the bedside during acute SJS, resulting in complete resolution. We concluded that the adjunctive application of ProKera® can be effective for ocular surface reconstruction and provides options to intervene earlier for outpatients or patients unstable for invasive surgical intervention. Full article
(This article belongs to the Special Issue Advances in the Diagnosis and Treatment of Ocular Surface Diseases: Volume II)
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9 pages, 14496 KiB  
Article
Sutureless Amniotic Membrane Transplantation in Inflammatory Corneal Perforations
by Alessandro Meduri, Antonio Valastro, Leandro Inferrera, Giovanni William Oliverio, Ivan Ninotta, Umberto Camellin, Maura Mancini, Anna Maria Roszkowska and Pasquale Aragona
Appl. Sci. 2022, 12(8), 3924; https://doi.org/10.3390/app12083924 - 13 Apr 2022
Cited by 6 | Viewed by 4922
Abstract
Introduction: The aim of this study was to evaluate the efficacy of sutureless amniotic membrane transplantation (SAMT) in patients with corneal perforation secondary to ocular surface inflammatory diseases. Methods: Twelve eyes of eleven patients with corneal perforation associated with Sjögren’s syndrome and ocular [...] Read more.
Introduction: The aim of this study was to evaluate the efficacy of sutureless amniotic membrane transplantation (SAMT) in patients with corneal perforation secondary to ocular surface inflammatory diseases. Methods: Twelve eyes of eleven patients with corneal perforation associated with Sjögren’s syndrome and ocular cicatricial pemphigoid were included. Surgical procedure consisted in the application of two layers of amniotic membrane covering the corneal perforation and a therapeutic contact lens placed above the two layers, followed by sutureless tarsorrhaphy with Steri-strip applied for 15 days to immobilize the eyelids. All patients underwent slit-lamp examination, fluorescein corneal staining, and anterior segment optical coherence tomography (AS-OCT), preoperatively and post-surgery, weekly for one month, and then every two weeks for three months. Results: All 12 eyes had complete resolution of corneal perforation. Pachymetry measurements improved in all eyes, and complete healing of the corneal ulcer was obtained following treatment and maintained up to 3 months follow-up in all patients. Conclusions: SAMT was proven to be a safe and effective option for the management of inflammatory corneal perforation. The procedure is non-traumatic and easy to perform since the surgical technique is sutureless and does not require topical therapy because it takes advantage of the intrinsic properties of the membrane itself. Full article
(This article belongs to the Special Issue Bioengineering Tools Applied to Medical and Surgical Sciences)
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8 pages, 801 KiB  
Article
AmnioClip-Plus as Sutureless Alternative to Amniotic Membrane Transplantation to Improve Healing of Ocular Surface Disorders
by Nicola Hofmann, Anna-Katharina Salz, Kristin Kleinhoff, Niklas Möhle, Martin Börgel, Nancy Diedenhofen and Katrin Engelmann
Transplantology 2021, 2(4), 425-432; https://doi.org/10.3390/transplantology2040040 - 18 Oct 2021
Cited by 4 | Viewed by 3338
Abstract
The medicinal benefits of amniotic membrane transplantation for ocular surface disorders are well accepted worldwide. Even in high-risk keratoplasties, the concomitant use of amniotic membrane has demonstrated its value in improving graft survival. However, its seam-associated application can lead to an additional trauma. [...] Read more.
The medicinal benefits of amniotic membrane transplantation for ocular surface disorders are well accepted worldwide. Even in high-risk keratoplasties, the concomitant use of amniotic membrane has demonstrated its value in improving graft survival. However, its seam-associated application can lead to an additional trauma. The AmnioClip ring system, into which the amniotic membrane is clamped (AmnioClip-plus, AC+), was developed to avoid this surgical intervention. The AC+ is placed on the cornea, similar to a contact lens, under local anesthesia and can therefore be applied repeatedly. Clinical practice demonstrates the easy handling, good compatibility, and efficacy of this minimally invasive method. Full article
(This article belongs to the Special Issue State-of-the-Art of Engineering and Regenerating Organs to Improve Graft Survival after Transplantation)
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