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Environmental degradation combined with the need to ensure food security for a rapidly growing world population has prompted the adoption of Sustainable Weed Management Practices (SWMPs), which are expected to reduce crop losses while preserving natural resources. However, evidence shows that farmers are reluctant to adopt them, and European farming remains dependent on chemical herbicides. The objective of this study is to analyze the adoption of SWMPs in Greece by identifying common factors that may explain the information (variance) included in each of two initial sets of variables, separately describing the following: (i) factors that hinder the adoption of SWMPs in Greece; (ii) factors and strategies to promote the use of SWMPs in the country. To achieve this purpose, 121 farmers cultivating annual arable crops in the Region of Thessaly in Central Greece were surveyed by means of a structured questionnaire. Using Principal Component Analysis (PCA) to reduce both initial sets of variables and categorize farmers’ responses into two smaller sets of uncorrelated components (dimensions) without missing valuable information, the analysis yielded five factors that limit the adoption of SWMPs (“Costs and availability of resources”; “Environment and land ownership”; “Compatibility and easiness of use”; “Economic performance”; “Social capital and education”) as well as four factors to promote their use (“Policy, research and Cooperatives”; “Training and mandatory regulations”; “Technology and networking”; “Targeted approaches”). The derived factors can be used in terms of policy objectives, as each dimension represents different aspects to be considered when developing effective strategies and integrated policies for the evolution and further expansion of SWMPs. Full article