Search Results (4)

In Thailand, wild yam, or Dioscorea hispida Dennst., is a starchy crop that is usually underutilized in industry. The purpose of this study was to isolate the starch and extract the phytochemical from D. hispida and use them in cosmetics. Starch was used instead of talcum, which can cause pulmonary talcosis in dusting powder formulas (DP 1-5). GC-MS was used to identify the bioactive components present in the ethanolic extract of D. hispida. The main compounds were identified as 9,12-octadecadienoic acid (Z,Z)- (6.51%), stigmasta-5,22-dien-3-ol, (3.beta.,22E)- (6.41%), linoleic acid ethyl ester (5.72%), (Z,Z)-9,12-octadeca-dienoic acid, 2,3-dihydroxy-propyl (3.89%), and campesterol (3.40%). Then, the extract was used as an ingredient in facial sleeping mask gel formulas (SM 1–SM 5). Stability tests, physical characteristics, enzyme inhibitions, and sensitization dermal toxicity tests were used to evaluate the DP and SM formulations. The results showed that the fresh tubers of D. hispida showed a 12.5% w/w starch content. The findings demonstrated that starch powder had a restricted size distribution, ranging from 2 to 4 μm, and a smooth surface that was polygonal. Following stability testing, the color, odor, size, and flowability of all DP formulations did not significantly differ. The SEM investigation revealed that DP particles were homogenous. For the sensitization dermal toxicity test, DP denoted no erythema or skin irritation in the guinea pigs. After stability testing, the colors of the SM formulas were deeper, and their viscosity slightly increased. The pH did not significantly change. After the stability test, SM formulas that contained Glycyrrhiza glabra and D. hispida extracts exhibited stable tyrosinase and elastase inhibitory activities, respectively. In the sensitization dermal toxicity test, guinea pigs showed skin irritation at level 2 (not severe) from SM, indicating that redness developed. All of these findings indicate that D. hispida is a plant that has potential for use in the cosmetics industry. Furthermore, D. hispida starch can be made into a beauty dusting powder, and more research should be conducted to develop an effective remedy for patients or those with skin problems. Full article

Digital self-tracking tools can be part of body work to measure, monitor, and optimise progress towards idealised versions of the self. Fitness and calorie trackers are obvious examples but menstrual tracking apps, which can track a large range of bodily ‘symptoms’, can also be part of body work. In this article, I present accounts of young people’s menstrual and fitness tracking experiences from existing literature, illustrating how both types of trackers can function as part of their users’ body work. I interweave these stories with an autoethnographic account of my own embodied experiences with and through menstrual and fitness tracking apps. I explore the ways in which health, beauty, and wellness can become enmeshed in self-tracking practices; how emotions, stress, and sleep can become personal problems to solve; how tracking tools can make body work feel more ‘real’; and the mutual but asymmetrical shaping of digital tracking tools and their users. Though there is an existing body of work on young people’s experiences of digital self-tracking tools more generally (particularly health and fitness tracking tools), young people’s use of menstrual tracking apps is a relatively understudied phenomenon to date. The themes identified in this article point towards possible avenues for future research. Full article

Inspired by the Monty Hall Problem and a popular simple solution to it, we present a number of game-show puzzles that are analogous to the notorious Sleeping Beauty Problem (and variations on it), but much easier to solve. We replace the awakenings of Sleeping Beauty by contestants on a game show, like Monty Hall’s, and increase the number of awakenings/contestants in the same way that the number of doors in the Monty Hall Problem is increased to make it easier to see what the solution to the problem is. We show that these game-show proxies for the Sleeping Beauty Problem and variations on it can be solved through simple applications of Bayes’s theorem. This means that we will phrase our analysis in terms of credences or degrees of belief. We will also rephrase our analysis, however, in terms of relative frequencies. Overall, our paper is intended to showcase, in a simple yet non-trivial example, the efficacy of a tried-and-true strategy for addressing problems in philosophy of science, i.e., develop a simple model for the problem and vary its parameters. Given that the Sleeping Beauty Problem, much more so than the Monty Hall Problem, challenges the intuitions about probabilities of many when they first encounter it, the application of this strategy to this conundrum, we believe, is pedagogically useful. Full article

In vivo gene delivery involves direct injection of nucleic acids (NAs) into tissues, organs, or tail-veins. It has been recognized as a useful tool for evaluating the function of a gene of interest (GOI), creating models for human disease and basic research targeting gene therapy. Cargo frequently used for gene delivery are largely divided into viral and non-viral vectors. Viral vectors have strong infectious activity and do not require the use of instruments or reagents helpful for gene delivery but bear immunological and tumorigenic problems. In contrast, non-viral vectors strictly require instruments (i.e., electroporator) or reagents (i.e., liposomes) for enhanced uptake of NAs by cells and are often accompanied by weak transfection activity, with less immunological and tumorigenic problems. Chromosomal integration of GOI-bearing transgenes would be ideal for achieving long-term expression of GOI. piggyBac (PB), one of three transposons (PB, Sleeping Beauty (SB), and Tol2) found thus far, has been used for efficient transfection of GOI in various mammalian cells in vitro and in vivo. In this review, we outline recent achievements of PB-based production of genetically modified animals and organs and will provide some experimental concepts using this system. Full article