Search Results (3)

Gulf War Illness (GWI) is a multi-symptom disorder affecting 1990–1991 Persian Gulf War veterans and is characterized by post-exertional malaise, neurological symptoms, immune deregulation, and exhaustion. Causation is not understood, and effective diagnostics and therapies have not yet been developed. In this work, we analyzed stress-related, sex-specific transcriptomic shifts in GWI subjects and healthy controls through RNA sequencing of peripheral blood mononuclear cells (PBMCs). Blood samples at baseline (T0), at maximal exertion (T1), and four hours post-exertion (T2) were analyzed. In female subjects with GWI, pathways associated with pro-inflammatory processes were found to be deregulated, and in male GWI subjects, pathways related to IL-12 signaling and lymphocytic activation were deregulated at T1 compared to T0. During recovery from stress, pathways corresponding to immune responses and microglial cell activation were altered in female GWI subjects, and apoptotic signaling changed in males with GWI. Documented sex-specific immune deregulation leads to finding better biomarkers. Targeting sex-specific transcriptomic markers of the disease could lead to new therapies for GWI. Full article

This study examined associations between COVID-19-related anxiety and sleep in middle-aged and older adults and tested whether these varied by age or sex. In June/July 2020, middle-aged/older adults aged 50+ (n = 277, 45% women, M_age = 64.68 ± 7.83) in the United States completed measures of sleep and COVID-19-related anxiety. Multiple regressions examined whether anxiety was independently associated with or interacted with age or sex in its associations with sleep health, controlling for age, education, medical conditions, sleep/pain medication use, and COVID-19 status. Greater COVID-19 anxiety was associated with worse sleep quality and daytime dysfunction. COVID-19-related anxiety interacted with age (not sex) in associations with total sleep time and sleep efficiency. Greater anxiety was associated with shorter total sleep time and lower sleep efficiency in oldest-older adults (~73 years old) and youngest-older adults (~65 years old) but not middle-aged adults (~57 years old). In mid to late life, older adults may be most vulnerable to the impact of COVID-19-related anxiety on sleep health. Social and behavioral (e.g., knowledge on age-related vulnerability to COVID-19 risk/morbidity/mortality, uncertainty, and changes to daily routines) and physiological factors (sleep disruption and age-related autonomic dysfunction) may underlie these associations. Interventions that mitigate negative pandemic-related psychological and sleep outcomes may be particularly relevant for older adults. Full article

In this paper, we shall examine some major religious roles for women in West Bengal, India, and the challenges they must face. Among the Santals, an Adivasi group, religious women must avoid being called witches, for women’s power is seen as dangerous and religious social roles are traditionally forbidden to them. Some women have been called by deities to become trance mediums, colloquially known as ‘bhar ladies’, and this role is generally not accepted by family members. Girls have had to undergo exorcisms by male healers to get them to renounce the gods that have called them to this role, while married women must deal with husbands who do not want their wives going into public trances. Many such women have learned tantric practices to control the trance possession. In rural areas, the combination of ascetic practices and stories known as bratas (vratas) are taught to young girls by female leaders called ayes. However, in more urban areas, this role has been taken over by male brahmin priests. We also see women in the bhakti tradition, who run ashrams and lead worship and who must deal with male devotees who question a woman’s leadership abilities. All of these involve challenges, and many of these women have developed strategies to deal with the difficulties of being a religious influencer in their societies. Full article