Search Results (6)

Background: Capsaicin is commonly used as a flavoring and a riot control agent. However, long-term exposure or high doses can cause acute lung injury in military and police personnel. The mechanisms underlying capsaicin-induced pulmonary toxicity remain unclear. Therefore, this study investigated the molecular mechanisms involved in capsaicin-induced acute lung injury using C57BL/6N mice. Methods: Through both transcriptomic and proteomic analyses of mouse lung tissue, we identified the involvement of the TNF signaling pathway in capsaicin-mediated acute lung injury. Next, we explored the role of TNF signaling in the progression of acute lung injury to identify potential therapeutic targets. In a capsaicin-induced acute lung injury mouse model and A549 cells, we assessed the therapeutic potential of the TNF-α antibody Nerelimomab. Compared with the control group, TNF-α up-regulation was observed, which correlated with increased pathological changes and elevated IL-6 (p < 0.01) and IL-18 (p < 0.01) levels, both in vivo and in vitro. Results: Flow cytometry revealed that compared to the capsaicin group, Nerelimomab treatment reduced the number of capsaicin-induced apoptotic cells (p < 0.001) and was associated with an increased Bcl-2/Bax ratio (p < 0.01) and reduced cleaved caspase 3 expression (p < 0.001). Analysis of A549 cells treated with capsaicin and Nerelimomab corroborated these results. These findings confirm the involvement of the TNF signaling pathway in capsaicin-induced acute lung injury and the apoptosis of alveolar epithelial cells. Conclusions: In conclusion, capsaicin inhalation can cause acute lung injury, and targeting the TNF signaling pathway offers a promising therapeutic strategy. Nerelimomab demonstrates significant potential in alleviating acute lung injury by inhibiting inflammatory mediator release and diminishing apoptosis. Based on transcriptomic and proteomic analyses, this study highlights the crucial role of the TNF signaling pathway in capsaicin-induced acute lung injury and supports the therapeutic efficacy of Nerelimomab in reducing epithelial apoptosis. Full article

The emergence of modern chemical weapons and chemical warfare is traditionally associated with World War I, but the use of poisons in the military has its roots deep in the past. The sources of these poisons have always been natural agents that also served as medicines. This relationship between poison and medicine, and nowadays between chemical warfare and medicine, or between ‘military chemistry’ and pharmacy, appears to be very important for understanding not only the history but also the possible future of both phenomena. This article looks at some historical examples of the use of drugs as chemical weapons and, conversely, the use of chemical weapons as medicines. It seeks to find answers to some questions that are particularly relevant to the implementation of the Chemical Weapons Convention, which aims to achieve a world without chemical warfare. Full article

In this study, we use restlessness as an input for a rice crisis indicator, since restlessness rather than rice price provides a comparable year-to year context. We outline the significant increase in the use of unprecedented restlessness (UR) as an indicator for rice crises. The UR approach involves a precedence analysis, in contrast with the existing approach, the price shock analysis. We test UR as a new indicator for rice crises at the national level, which can be applied in Asia and other countries around the world where rice is the staple food. Strong indicators point out the effectiveness of strategic government programs and are able to assess solutions and detect rice crises, while weak indicators are only reliable in detecting whether or not there has been a crisis. UR is tested across 43 countries using two new statistics: success probability (SP) and constraint probability (CP). As a consequence of SP and CP calculations, a large number of IMR control charts for UR analysis are constructed to provide evidence that UR is a strong indicator. The optimum validity measurement result is achieved with SP = 8/26 = 0.31 and CP = 8/14 = 0.57. This means that the UR detects and is followed by only 31% of riot events. Since the value of SP is less than 0.6, we can conclude that the UR indicator is not considered valid as an indicator of rice crises at the national level. The values of CP and SP are determined subjectively as equal to 0.6. This is the main cause of the emergence of new problems in the calibration of UR as an indicator of rice crises. The subjective success criteria trigger a question regarding why the value is 0.6, for which there is no scientific justification. Based on this background, we continue to objectively establish success criteria for UR validity. After conducting a risk analysis involving a crisis recovery cost (CRC) to crisis anticipation cost (CAC) ratio, it is found that the probability of the CRC-to-CAC ratio having values greater than 7 is 0.76, which means the CRC-to-CAC ratio tends to be higher than 7. Objectively, it is concluded that UR, which has been defined as rice crisis indicator at the national level, is an important indicator. Full article

SARS-CoV-2, a tiny virus, is severely affecting the social, economic, and environmental sustainability of our planet, causing infections and deaths (2,674,151 deaths, as of 17 March 2021), relationship breakdowns, depression, economic downturn, riots, and much more. The lessons that have been learned from good practices by various countries include containing the virus rapidly; enforcing containment measures; growing COVID-19 testing capability; discovering cures; providing stimulus packages to the affected; easing monetary policies; developing new pandemic-related industries; support plans for controlling unemployment; and overcoming inequalities. Coordination and multi-term planning have been found to be the key among the successful national and global endeavors to fight the pandemic. The current research and practice have mainly focused on specific aspects of COVID-19 response. There is a need to automate the learning process such that we can learn from good and bad practices during pandemics and normal times. To this end, this paper proposes a technology-driven framework, iResponse, for coordinated and autonomous pandemic management, allowing pandemic-related monitoring and policy enforcement, resource planning and provisioning, and data-driven planning and decision-making. The framework consists of five modules: Monitoring and Break-the-Chain, Cure Development and Treatment, Resource Planner, Data Analytics and Decision Making, and Data Storage and Management. All modules collaborate dynamically to make coordinated and informed decisions. We provide the technical system architecture of a system based on the proposed iResponse framework along with the design details of each of its five components. The challenges related to the design of the individual modules and the whole system are discussed. We provide six case studies in the paper to elaborate on the different functionalities of the iResponse framework and how the framework can be implemented. These include a sentiment analysis case study, a case study on the recognition of human activities, and four case studies using deep learning and other data-driven methods to show how to develop sustainability-related optimal strategies for pandemic management using seven real-world datasets. A number of important findings are extracted from these case studies. Full article

Flexible surge capacity aims to activate and utilize other resources than normally are surged in a community during the primary and secondary surge capacity. The presence of alternative leadership, skilled and knowledgeable in hospital and prehospital emergency management, is invaluable. Thai emergency physicians work at both levels, emphasizing their important role in emergency management of any source in a disaster-prone country. We aimed to investigate Thai emergency physicians’ ability in terms of knowledge and preparedness to manage potential emergencies using tabletop simulation exercises. Using an established method for training collaboration, two training courses were arranged for over 50 Thai emergency physicians, who were divided into three teams of prehospital, hospital, and incident command groups. Three scenarios of a terror attack along with a bomb explosion, riot, and shooting, and high building fire were presented, and the participants’ performance was evaluated regarding their preparedness, response and gained knowledge. Two senior observers followed the leadership characteristic in particular. Thai physicians’ perceived ability in command and control, communication, collaboration, coordination, and situation assessment improved in all groups systematically. New perspectives and innovative measures were presented by participants, which improved the overall management on the final day. Tabletop simulation exercise increased the perceived ability, knowledge, and attitude of Thai emergency physicians in managing major incidents and disasters. It also enabled them to lead emergency management in a situation when alternative leadership is a necessity as part of the concept of a flexible surge capacity response system. Full article

o-Chlorobenzylidene malononitrile (CS) is one of the most extensively used riot control agents. Our aim was to conduct a systematic review of the potential health effects related to CS exposure. We searched for papers in English between 1991 and 2014. Thirty five (35) studies (25 case reports, seven descriptive studies and three analytical studies) were included in the review. In the twenty five case reports/series 90 cases of exposure to CS and their clinical effects are presented. Their mean age was 25.7 years and 62.0% were males. In addition, 61% of the cases described dermal, 40% respiratory, 57% ocular clinical effects. Life threatening situations as well as long-term health effects were found and were related with exposure to confined/enclosed space. Descriptive and analytical studies have shown attack rates ranging from 12% to 40%. Subjects who were sprayed by the police more often needed special treatment and reported adverse health effects. Apart from transient clinical effects, CS could have lasting and serious effects on human health. Better surveillance of the subjects exposed to CS and completion of cohort studies among exposed populations will illuminate the spectrum of the health effects of exposure to CS. Full article