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Keywords = pyrroloquinoline skeleton

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13 pages, 3926 KB  
Article
H2O2/Glucose Sensor Based on a Pyrroloquinoline Skeleton-Containing Molecule Modified Gold Cavity Array Electrode
by Kaiyue Wang, Xuefang Gu, Qun Zhao, Xinyi Shao, Yaqi Xiao, Chongyu Zhong, Shu Tian and Bing Yang
Nanomaterials 2022, 12(10), 1770; https://doi.org/10.3390/nano12101770 - 23 May 2022
Cited by 2 | Viewed by 2249
Abstract
H2O2-related metabolites are essential indicators in clinical diagnosis because the accumulation of such reactive oxygen species could cause the risk of cardiovascular disease. Herein, we reported an electrochemical sensor to determine H2O2 and glucose. The pyrroloquinoline [...] Read more.
H2O2-related metabolites are essential indicators in clinical diagnosis because the accumulation of such reactive oxygen species could cause the risk of cardiovascular disease. Herein, we reported an electrochemical sensor to determine H2O2 and glucose. The pyrroloquinoline skeleton containing molecules (PQT) were used as the electrocatalyst and the gold cavity array (GCA) electrodes as the supporting electrode. The GCA electrode was fabricated by electrodeposition using high-ordered two-dimensional polystyrene spheres as the template. The strong absorbability of iodide ions (I) displaced adventitious materials from the metal surface and the I monolayer was subsequently removed by electrochemical oxidation to get a clean electrode surface. PQT molecules were firmly immobilized on the GCA electrode and performed an excellent electrocatalytic effect on H2O2/glucose detection, manifested by a small overpotential and a significantly increased reduction current. A good linear correlation was observed over a wide range of 0.2 μmol/L–1.0 mmol/L with the limit of detection of 0.05 μmol/L. Moreover, the sensor can realize sensitive, accurate, and the highly selective detection of actual samples, proving its application prospect in clinical diagnosis. Full article
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8 pages, 1201 KB  
Communication
Synthesis of Proposed Structure of Aaptoline B via Transition Metal-Catalyzed Cycloisomerization and Evaluation of Its Neuroprotective Properties in C. Elegans
by Soobin Kim, Wooin Yang, Young-Taek Han and Dong-Seok Cha
Appl. Sci. 2021, 11(19), 9125; https://doi.org/10.3390/app11199125 - 30 Sep 2021
Cited by 3 | Viewed by 2097
Abstract
A concise synthesis of the proposed structure of aaptoline B, a pyrroloquinoline derived from a marine sponge, was accomplished. A key feature of this synthesis is the versatile transition metal-catalyzed cycloisomerization of N-propargylaniline to construct a quinoline skeleton. However, the spectral data [...] Read more.
A concise synthesis of the proposed structure of aaptoline B, a pyrroloquinoline derived from a marine sponge, was accomplished. A key feature of this synthesis is the versatile transition metal-catalyzed cycloisomerization of N-propargylaniline to construct a quinoline skeleton. However, the spectral data of the synthesized aaptoline B did not agree with those of previous studies. The structure of the synthesized aaptoline B was confirmed using a combined 2D NMR analysis. Furthermore, we assessed the possible neuroprotective potential of aaptoline B using the C. elegans model system. In this study, aaptoline B significantly improved the viability and the morphology of dopaminergic neurons of nematodes under MPP+ exposure conditions. We also found that MPP+-induced motor deficits in nematodes were efficiently restored by aaptoline B treatment. Our findings demonstrate the neuroprotective effects of aaptoline B against MPP+-induced dopaminergic neuronal damage. Further studies are underway to explain its pharmacological mechanism. Full article
(This article belongs to the Special Issue Advances on Applications of Bioactive Natural Compounds)
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