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Keywords = pyrazolylamine

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Article
Studies with β-Oxoalkanonitriles: Simple Novel Synthesis of 3-[2,6-Diaryl-4- pyridyl]-3-oxopropanenitriles
by Sayed M. Riyadh, Hamad M. Al-Matar and Mohamed H. Elnagdi
Molecules 2008, 13(12), 3140-3148; https://doi.org/10.3390/molecules13123140 - 15 Dec 2008
Cited by 11 | Viewed by 10639
Abstract
Heteroaromatization of ethyl 2-cyano-4-oxo-2-(2-oxo-2-arylethyl)-4-arylbutanoates 3a,b with ammonium acetate gave ethyl 2,6-diarylisonicotinates 4a,b. Treatment of the latter with acetonitrile afforded novel β-oxoalkanonitriles 6a,b. Reactions of 6a,b with phenyl hydrazine and hydroxylamine gave the corresponding pyridyl aminopyrazoles 8a,b and pyridyl aminoisoxazoles 10a,b, respectively. Full article
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