Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Journals

Article Types

Countries / Regions

Search Results (2)

Search Parameters:
Keywords = poly(magnesium acrylate)

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
15 pages, 1323 KB  
Article
Controlled Release of Highly Hydrophilic Drugs from Novel Poly(Magnesium Acrylate) Matrix Tablets
by Rebeca Simancas-Herbada, Ana Fernández-Carballido, Juan Aparicio-Blanco, Karla Slowing, Jorge Rubio-Retama, Enrique López-Cabarcos and Ana-Isabel Torres-Suárez
Pharmaceutics 2020, 12(2), 174; https://doi.org/10.3390/pharmaceutics12020174 - 19 Feb 2020
Cited by 18 | Viewed by 5295
Abstract
The potential of a new poly(magnesium acrylate) hydrogel (PAMgA) as a pharmaceutical excipient for the elaboration of matrix tablets for the extended release of highly hydrophilic drugs was evaluated. The polymer was synthetized with two different crosslinking degrees that were characterized by FTIR [...] Read more.
The potential of a new poly(magnesium acrylate) hydrogel (PAMgA) as a pharmaceutical excipient for the elaboration of matrix tablets for the extended release of highly hydrophilic drugs was evaluated. The polymer was synthetized with two different crosslinking degrees that were characterized by FTIR and DSC. Their acute oral toxicity was determined in a mouse model, showing no toxicity at doses up to 10 g/kg. Matrix tablets were prepared using metformin hydrochloride as a model drug and the mechanisms involved in drug release (swelling and/or erosion) were investigated using biorrelevant media. This new hydrogel effectively controlled the release of small and highly hydrophilic molecules as metformin, when formulated in matrix tablets for oral administration. The rate of metformin release from PAMgA matrices was mainly controlled by its diffusion through the gel layer (Fickian diffusion). The swelling capacity and the erosion of the matrix tablets influenced the metformin release rate, that was slower at pH 6.8, where polymer swelling is more intensive, than in gastric medium, where matrix erosion is slightly more rapid. The crosslinking degree of the polymer significantly influenced its swelling capacity in acid pH, where swelling is moderate, but not in intestinal fluid, where swelling is more intense. Full article
Show Figures

Graphical abstract

8 pages, 2772 KB  
Article
The Combined Effects of Sr(II) and Poly(Acrylic Acid) on the Morphology of Calcite
by Hak Yeong Kim, Taewook Yang, Wansoo Huh, Young-Je Kwark, Yunsang Lee and Il Won Kim
Materials 2019, 12(20), 3339; https://doi.org/10.3390/ma12203339 - 13 Oct 2019
Cited by 4 | Viewed by 2984
Abstract
Biomineralization of calcium carbonate has interesting characteristics of intricate morphology formation with controlled crystal polymorphs. In particular, modification of calcite morphology with diverse additives has been the focus of many biomimetic and bioinspired studies. The possible role of strontium ions in enhancing the [...] Read more.
Biomineralization of calcium carbonate has interesting characteristics of intricate morphology formation with controlled crystal polymorphs. In particular, modification of calcite morphology with diverse additives has been the focus of many biomimetic and bioinspired studies. The possible role of strontium ions in enhancing the morphology-modifying ability of macromolecules was investigated. In the present study, concentrations of strontium ions were comparable to that in seawater, and anionic poly(acrylic acid) and cationic poly(ethylene imine) were used as model macromolecules. When strontium ions were combined with anionic poly(acrylic acid), new types of calcite surfaces, most likely {hk0}, appeared to drastically change the morphology of the crystals, which was not observed with cationic poly(ethylene imine). This behavior of strontium ions was quite similar to that of magnesium ions, which is intriguing because both ions are available from seawater to be utilized during biomineralization. Full article
(This article belongs to the Special Issue Growth and Design of Inorganic Crystal)
Show Figures

Figure 1

Back to TopTop