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Keywords = photocontrolled chemotherapeutics

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31 pages, 7227 KiB  
Review
Recent Advances in Light-Controlled Activation of Pt(IV) Prodrugs
by Daniil Spector, Kirill Pavlov, Elena Beloglazkina and Olga Krasnovskaya
Int. J. Mol. Sci. 2022, 23(23), 14511; https://doi.org/10.3390/ijms232314511 - 22 Nov 2022
Cited by 19 | Viewed by 3209
Abstract
Pt(IV) prodrugs remain one of the most promising alternatives to conventional Pt(II) therapy due to their versatility in axial ligand choice and delayed mode of action. Selective activation from an external source is especially attractive due to the opportunity to control the activity [...] Read more.
Pt(IV) prodrugs remain one of the most promising alternatives to conventional Pt(II) therapy due to their versatility in axial ligand choice and delayed mode of action. Selective activation from an external source is especially attractive due to the opportunity to control the activity of an antitumor drug in space and time and avoid damage to normal tissues. In this review, we discuss recent advances in photoabsorber-mediated photocontrollable activation of Pt(IV) prodrugs. Two main approaches developed are the focus of the review. The first one is the photocatalytic strategy based on the flavin derivatives that are not covalently bound to the Pt(IV) substrate. The second one is the conjugation of photoactive molecules with the Pt(II) drug via axial position, yielding dual-action Pt(IV) molecules capable of the controllable release of Pt(II) cytotoxic agents. Thus, Pt(IV) prodrugs with a light-controlled mode of activation are non-toxic in the absence of light, but show high antiproliferative activity when irradiated. The susceptibility of Pt(IV) prodrugs to photoreduction, photoactivation mechanisms, and biological activity is considered in this review. Full article
(This article belongs to the Special Issue Materials for Bioengineering and Biotechnology)
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