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Keywords = phelligridin G

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16 pages, 474 KB  
Review
Current Knowledge of Medicinal Mushrooms Related to Anti-Oxidant Properties
by Shifa Shaffique, Sang-Mo Kang, Ah-Yeong Kim, Muhammad Imran, Muhammad Aaqil Khan and In-Jung Lee
Sustainability 2021, 13(14), 7948; https://doi.org/10.3390/su13147948 - 16 Jul 2021
Cited by 41 | Viewed by 7459
Abstract
Background: A renewed focus on medicinal mushrooms has brought forth a sustainable health dimension. Conventional health strategies are insufficiently integrated with sustainable health promotion. The health-promoting outcome of mushrooms has fascinated many groups during the past few years because of various primary and [...] Read more.
Background: A renewed focus on medicinal mushrooms has brought forth a sustainable health dimension. Conventional health strategies are insufficiently integrated with sustainable health promotion. The health-promoting outcome of mushrooms has fascinated many groups during the past few years because of various primary and secondary metabolites in different cellular components. They contain many bioactive metabolites, including proteins (cytokines, ergothioneine), fibers, moisture, carbohydrates (uronic acid), folate, thiamine, ascorbic acid, vitamin D, calcium, potassium, polysaccharides (G. lucidum polysaccharides, alpha and beta glucans, and lentinan) polyketides, polyphenols (Protocatechuic acid, inonoblins A–vanillic acid, phelligridins D, E, and G, hydroxybenzoic acid, gallic acid, tannic acid, hispidine, gentisic acid, and tocopherol), nucleotides (adenosine, cordycepin), lovastatin, steroids, alkaloids, and sesquiterpenes. Objective: This study was conducted to gather information on the current knowledge of medicinal mushrooms, with respect to their antioxidant properties. Conclusions: The results indicated that mushrooms are a promising source of natural antioxidants. Of all mushrooms, the Ganoderma tsugae Murill exhibited an excellent antioxidant potential of 93.7–100% at 20 mg/mL. Full article
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11 pages, 310 KB  
Article
The Tandem Ring Opening/Ring Closing Metathesis Route to Oxaspirocycles: An Approach to Phelligridin G
by Harold D. Cooper and Dennis L. Wright
Molecules 2013, 18(2), 2438-2448; https://doi.org/10.3390/molecules18022438 - 21 Feb 2013
Cited by 11 | Viewed by 6980
Abstract
Phelligridin G is an unusual natural product that contains an embedded spiro-fused furanone core. We have investigated two furan-based synthetic approaches towards the spirocyclic core structure of this natural product from readily available 2-phenylfurans. Although initial studies involving an oxidative cyclization were unsuccessful, [...] Read more.
Phelligridin G is an unusual natural product that contains an embedded spiro-fused furanone core. We have investigated two furan-based synthetic approaches towards the spirocyclic core structure of this natural product from readily available 2-phenylfurans. Although initial studies involving an oxidative cyclization were unsuccessful, we were ultimately able to access this key system through a sequential intermolecular furan Diels-Alder reaction followed by a metathesis-based reorganization. A related approach led to an expanded C ring to form spiro-fused pyran spirocycles. Full article
(This article belongs to the Special Issue Spiro Compounds)
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