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Keywords = outer retinal tubulations

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19 pages, 2616 KiB  
Review
Optical Coherence Tomography and Clinicopathological Correlation for Understanding the Pathogenic, Clinical, and Prognostic Implications in Age-Related Macular Degeneration
by Serena Fragiotta, Mariachiara Di Pippo, Daniele Fumi, Chiara Ciancimino and Solmaz Abdolrahimzadeh
Photonics 2025, 12(3), 237; https://doi.org/10.3390/photonics12030237 - 5 Mar 2025
Viewed by 1096
Abstract
Optical coherence tomography (OCT) has emerged as a pivotal imaging modality in elucidating the pathogenic, clinical, and prognostic implications of age-related macular degeneration (AMD). This review examines the utility of OCT in providing high-resolution, cross-sectional imaging of retinal structures comparable to an in [...] Read more.
Optical coherence tomography (OCT) has emerged as a pivotal imaging modality in elucidating the pathogenic, clinical, and prognostic implications of age-related macular degeneration (AMD). This review examines the utility of OCT in providing high-resolution, cross-sectional imaging of retinal structures comparable to an in vivo histopathology. Recent histopathological correlations with OCT have enabled the precise characterization of AMD extracellular lesions, improving the interpretation of several OCT signatures. By correlating OCT findings with clinicopathological features, a deeper understanding of the underlying pathophysiology of AMD is achieved, facilitating early detection, risk stratification, and therapeutic decision making. Furthermore, OCT-derived biomarkers offer valuable insights into disease severity, response to treatment, and prognostic outcomes, thereby enhancing patient care and optimizing visual outcomes. Full article
(This article belongs to the Special Issue OCT Technology Advances and Their Applications in Disease Studies)
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