Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline
remove_circle_outline

Journals

Article Types

Countries / Regions

Search Results (1)

Search Parameters:
Keywords = norseterterpene

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
26 pages, 3735 KiB  
Review
Marine Terpenic Endoperoxides
by Irene Torres-García, Josefa L. López-Martínez, Manuel Muñoz-Dorado, Ignacio Rodríguez-García and Miriam Álvarez-Corral
Mar. Drugs 2021, 19(12), 661; https://doi.org/10.3390/md19120661 - 25 Nov 2021
Cited by 8 | Viewed by 3096
Abstract
Organic extracts of marine invertebrates, mainly sponges, from seas all over the world are well known for their high in vitro anticancer and antibiotic activities which make them promising sources of compounds with potential use as pharmaceutical leads. Most of the structures discovered [...] Read more.
Organic extracts of marine invertebrates, mainly sponges, from seas all over the world are well known for their high in vitro anticancer and antibiotic activities which make them promising sources of compounds with potential use as pharmaceutical leads. Most of the structures discovered so far have a peculiar structural feature in common: a 1,2-dioxane ring. This is a highly reactive heterocycle that can be considered as an endoperoxide function. Together with other structural features, this group could be responsible for the strong biological activities of the substances present in the extracts. Numerous research programs have focused on their structural elucidation and total synthesis since the seventies. As a consequence, the number of established chiral centres and the similarity between different naturally occurring substances is increasingly higher. Most of these compounds have a terpenoid nature, mainly diterpene and sesterterpene, with several peculiar structural features, such as the loss of one carbon atom. Although there are many reviews dealing with the occurrence of marine peroxides, their activities, or potential pharmaceutical uses, no one has focused on those having a terpene origin and the endoperoxide function. We present here a comprehensive review of these compounds paying special attention to their structural features and their biological activity. Full article
(This article belongs to the Special Issue Marine Drugs Research in Spain)
Show Figures

Figure 1

Back to TopTop