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Keywords = non-cell-autonomous toxicity Nrf2

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16 pages, 984 KB  
Review
Activation of the Nrf2 Pathway as a Therapeutic Strategy for ALS Treatment
by Liaisan Arslanbaeva and Marco Bisaglia
Molecules 2022, 27(5), 1471; https://doi.org/10.3390/molecules27051471 - 22 Feb 2022
Cited by 18 | Viewed by 4314
Abstract
Amyotrophic lateral sclerosis is a progressive and fatal disease that causes motoneurons degeneration and functional impairment of voluntary muscles, with limited and poorly efficient therapies. Alterations in the Nrf2-ARE pathway are associated with ALS pathology and result in aberrant oxidative stress, making the [...] Read more.
Amyotrophic lateral sclerosis is a progressive and fatal disease that causes motoneurons degeneration and functional impairment of voluntary muscles, with limited and poorly efficient therapies. Alterations in the Nrf2-ARE pathway are associated with ALS pathology and result in aberrant oxidative stress, making the stimulation of the Nrf2-mediated antioxidant response a promising therapeutic strategy in ALS to reduce oxidative stress. In this review, we first introduce the involvement of the Nrf2 pathway in the pathogenesis of ALS and the role played by astrocytes in modulating such a protective pathway. We then describe the currently developed activators of Nrf2, used in both preclinical animal models and clinical studies, taking into consideration their potentialities as well as the possible limitations associated with their use. Full article
(This article belongs to the Section Natural Products Chemistry)
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