Search Results (7)

Background: The identification of pathogenic variants in the Breast Cancer Genes 1 and 2 (BRCA1/2) is a critical predictive biomarker for poly (ADP-ribose) polymerase inhibitor (PARPi) therapy in epithelial ovarian cancer (EOC). The aim of this study is to define real-world rates and determinants of germline and somatic BRCA1/2 testing and subsequent PARPi utilisation in Australia using a national clinical quality registry. Methods: This multi-centre cohort study analysed data from 1503 women with non-mucinous EOC diagnosed between May 2017 and July 2022, captured by the Australian National Gynae-Oncology Registry (NGOR). We evaluated rates of germline and somatic testing and PARPi use, using multivariate logistic regression to identify associated clinical and demographic factors. Results: Overall germline and somatic testing rates were 68% and 32%, respectively. For the high-grade serous ovarian cancer (HGSOC) cohort, rates were higher, at 78% and 39%, respectively. Germline testing was significantly less likely for women aged >80 years (OR 0.49), those in regional areas (OR 0.61), and those receiving single-modality treatment. Somatic testing uptake increased significantly following public reimbursement for PARPi (p = 0.004). Among eligible women with a newly diagnosed BRCA pathogenic variant and advanced disease (n = 110), 52% commenced first-line maintenance PARPi. Conclusions: This national study offers valuable insights into Australian ovarian cancer care, highlighting opportunities to enhance testing equity for older women (aged >80) and regional patients. Furthermore, it identifies the translation of a positive test into PARPi therapy as a complex area that warrants further collaborative investigation to optimise patient outcomes. Full article

The primary aim of this study was to assess the investment activity of basic local government units in the development of renewable energy sources co-financed by EU funds depending on CO₂ emissions and other socio-economic conditions in terms of regions of Poland in the years 2007–2020. Empirical studies aimed at the verification of the research hypothesis that “the greatest investment activity in local projects co-financed from EU funds related to the development of renewable energy sources is observed for local government units in regions with highest CO₂ emissions”. Empirical studies were conducted based on data from the Ministry of Investment and Economic Development in Poland, the Local Data Bank, and the National Centre for Emissions Management. Thus, the conducted analyses provide both cognitive and applicatory values for the establishment of an appropriate energy transition policy in individual regions of Poland, which may be implemented by local government authorities within the current financial framework. Data concerning CO₂ emissions at the regional level were estimated by applying the original disaggregation method as modified by the authors, which made it possible to fill the research gap resulting from the lack of data on emissions at the regional level. In order to show the regional diversification in investment activity of local government units in terms of renewable energy sources, its multi-faceted analysis was conducted by applying the Ward method. Clusters of regions with similar investment activity of local government units were described based on characteristics included in the typological classification (so-called active characteristics) and selected indexes showing CO₂ emission levels, as well as selected socio-economic indexes (so-called passive characteristics). Based on the empirical studies, the research hypothesis presented in this paper was negatively verified. Considering both multiannual financial frameworks, the EU financial support for the development of renewable energy sources was used primarily by local government units of a predominantly agricultural character, and less advanced in terms of their development but exhibiting conditions conducive to renewable energy development. Full article

Background: Cell and/or tissue-based wound care products have slowly advanced in the treatment of non-healing ulcers, however, few studies have evaluated the effectiveness of these devices in the management of severe diabetic foot ulcers. Method: This study (KereFish) is part of a multi-national, multi-centre, randomised, controlled clinical investigation (Odin) with patients suffering from deep diabetic wounds, allowing peripheral artery disease as evaluated by an ankle brachial index equal or higher than 0.6. The study has parallel treatment groups: Group 1 treatment with Kerecis^® Omega3 Wound™ versus Group 2 treatment with standard of care. The primary objective is to test the hypothesis that a larger number of severe diabetic ulcers and amputation wounds, including those with moderate arterial disease, will heal in 16 weeks when treated with Kerecis^® Omega3 Wound™ than with standard of care. Conclusion: This study has received the ethics committee approval of each participating country. Inclusion of participants began in March 2020 and ended in July 2022. The first results will be presented in March 2023. The study is registered in ClinicalTrials.gov as Identifier: NCT04537520. Full article

Temperature is one of the most important meteorological variables for global climate change and human sustainable development. It plays an important role in agroclimatic regionalization and crop production. To date, temperature data have come from a wide range of sources. A detailed understanding of the reliability and applicability of these data will help us to better carry out research in crop modelling, agricultural ecology and irrigation. In this study, temperature reanalysis products produced by the China Meteorological Administration Land Data Assimilation System (CLDAS), the U.S. Global Land Data Assimilation System (GLDAS) and the European Centre for Medium-Range Weather Forecasts (ECMWF) Reanalysis version5 (ERA5)-Land are verified against hourly observations collected from 2265 national automatic weather stations (NAWS) in China for the period 2017–2019. The above three reanalysis systems are advanced and widely used multi-source data fusion and re-analysis systems at present. The station observations have gone through data Quality Control (QC) and are taken as “true values” in the present study. The three reanalysis temperature datasets were spatial interpolated using the bi-linear interpolation method to station locations at each time. By calculating the statistical metrics, the accuracy of the gridded datasets can be evaluated. The conclusions are as follows. (1) Based on the evaluation of temporal variability and spatial distribution as well as correlation and bias analysis, all the three reanalysis products are reasonable in China. (2) Statistically, the CLDAS product has the highest accuracy with the root mean square error (RMSE) of 0.83 °C. The RMSEs of the other two reanalysis datasets produced by ERA5-Land and GLDAS are 2.72 °C and 2.91 °C, respectively. This result indicates that the CLDAS performs better than ERA5-Land and GLDAS, while ERA5-Land performs better than GLDAS. (3) The accuracy of the data decreases with increasing elevation, which is common for all of the three products. This implies that more caution is needed when using the three reanalysis temperature data in mountainous regions with complex terrain. The major conclusion of this study is that the CLDAS product demonstrates a relatively high reliability, which is of great significance for the study of climate change and forcing crop models. Full article

In recent years, different space agencies have launched satellite missions that carry passive microwave instruments on-board that can measure surface soil moisture. Three currently operational missions are the Soil Moisture and Ocean Salinity (SMOS) mission developed by the European Space Agency (ESA), the Advanced Microwave Scanning Radiometer 2 (AMSR2) developed by the Japan Aerospace Exploration Agency (JAXA), and the Microwave Radiation Imager (MWRI) from China’s National Satellite Meteorological Centre (NSMC). In this study, the quality of surface soil moisture anomalies derived from these passive microwave instruments was sequentially assessed over the mainland of the People’s Republic of China. First, the impact of a recent update in the Land Parameter Retrieval Model (LPRM) was assessed for MWRI observations. Then, the soil moisture measurements retrieved from the X-band observations of MWRI were compared with those of AMSR2, followed by an internal comparison of the multiple frequencies of AMSR2. Finally, SMOS retrievals from two different algorithms were also included in the comparison. For each sequential step, processing and verification chains were specifically designed to isolate the impact of algorithm (version), observation frequency or instrument characteristics. Two verification techniques are used: the statistical Triple Collocation technique is used as the primary verification tool, while the precipitation-based R_value technique is used to confirm key results. Our results indicate a consistently better performance throughout the entire study area after the implementation of an update of the LPRM. We also find that passive microwave observations in the AMSR2 C-band frequency (6.9 GHz) have an advantage over the AMSR2 X-band frequency (10.7 GHz) over moderate to densely vegetated regions. This finding is in line with theoretical expectations as emitted soil radiation will become masked under a dense canopy with stricter thresholds for higher passive microwave frequencies. Both AMSR2 and MWRI make X-band observations; a direct comparison between them reveals a consistently higher quality obtained by AMSR2, specifically over semi-arid climate regimes. Unfortunately, Radio Frequency Interference hampers the usefulness of soil moisture products for the SMOS L-band mission, leading to a significantly reduced revisit time over the densely populated eastern part of the country. Nevertheless, our analysis demonstrates that soil moisture products from a number of multi-frequency microwave sensors are credible alternatives for this dedicated L-band mission over the mainland of the People’s Republic of China. Full article

The Humanities have a problem with visibility both in the public sphere and in the academic system itself, and they have an organisational problem when compared with other sections of the academic system. They also have a funding problem, particularly in a European context, i.e., in the framework of the European research policy. The topic of this position paper is the essential role of the Humanities when dealing with the European project, the framing of Europe. In this respect, in contrast to the natural and social sciences, the Humanities need specific models of research funding, more individualised and of more interdisciplinary character. Additionally, they may need more multi-national centres for advanced studies on a European level, thus also solving their visibility and organisational problems. Full article

This article discusses a business-school collaborative learning partnership in the Regional Centre of Expertise (RCE) on Education for Sustainable Development (ESD) in Greater Sendai. This partnership is further linked to a broader context of multi-stakeholder public participation in the RCE that was set up to advance the ESD agenda in the region. The authors propose a conceptual framework for multi-stakeholder, ESD-based social learning within the RCE with the aim of enabling the creation of a sustainability-literate society. This proposal is based on the results of students’ prior experience in ESD activities, optimal age for ESD learning and future job choices presented in this paper, together with a reported article that the levels of sustainability of the two sectoral organizations were mixed and hence need improvement. The paper argues that it will be good to focus on bridging the business and education sectors by building ESD capacity of the children and youth in the formal education sector. It contends this could be done through collaborative learning using the government-mandated “Period of Integrated Studies” (PIS) in the Japanese primary and secondary school curriculum. Additionally, it will be appropriate for the RCE Greater Sendai Steering Committee to facilitate and coordinate the learning processes and also promote networking and cooperative interactions among the actors and stakeholders in the region. Recommendations for improvement of the learning partnerships in RCE Greater Sendai are made for consideration at the local and national policy levels. Full article