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Keywords = mitochondriopathia

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24 pages, 2306 KiB  
Review
Role of Creatine Supplementation in Conditions Involving Mitochondrial Dysfunction: A Narrative Review
by Robert Percy Marshall, Jan-Niklas Droste, Jürgen Giessing and Richard B. Kreider
Nutrients 2022, 14(3), 529; https://doi.org/10.3390/nu14030529 - 26 Jan 2022
Cited by 20 | Viewed by 20680
Abstract
Creatine monohydrate (CrM) is one of the most widely used nutritional supplements among active individuals and athletes to improve high-intensity exercise performance and training adaptations. However, research suggests that CrM supplementation may also serve as a therapeutic tool in the management of some [...] Read more.
Creatine monohydrate (CrM) is one of the most widely used nutritional supplements among active individuals and athletes to improve high-intensity exercise performance and training adaptations. However, research suggests that CrM supplementation may also serve as a therapeutic tool in the management of some chronic and traumatic diseases. Creatine supplementation has been reported to improve high-energy phosphate availability as well as have antioxidative, neuroprotective, anti-lactatic, and calcium-homoeostatic effects. These characteristics may have a direct impact on mitochondrion’s survival and health particularly during stressful conditions such as ischemia and injury. This narrative review discusses current scientific evidence for use or supplemental CrM as a therapeutic agent during conditions associated with mitochondrial dysfunction. Based on this analysis, it appears that CrM supplementation may have a role in improving cellular bioenergetics in several mitochondrial dysfunction-related diseases, ischemic conditions, and injury pathology and thereby could provide therapeutic benefit in the management of these conditions. However, larger clinical trials are needed to explore these potential therapeutic applications before definitive conclusions can be drawn. Full article
(This article belongs to the Special Issue Creatine Supplementation for Health and Clinical Diseases)
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