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Keywords = micrometam C

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13 pages, 1363 KiB  
Article
Micrometam C Protects against Oxidative Stress in Inflammation Models in Zebrafish and RAW264.7 Macrophages
by Hao Tang, Hui Ge, Zhi-Bin Chen, Xiong-Ming Luo, Feng-Juan Su, Yan-Bing Liang, Zhen-Yu Li, Jing-Guo Wu, Qing Yang, Li-Jin Zeng and Zhong-Fu Ma
Mar. Drugs 2015, 13(9), 5593-5605; https://doi.org/10.3390/md13095593 - 28 Aug 2015
Cited by 16 | Viewed by 6398
Abstract
Micrometam C is a core of novel marine compound isolated from the mangrove associates Micromelum falcatum. In this study, we investigated the protective effects of micrometam C in inflammation models in the transgenic zebrafish line Tg (corola: eGFP) and RAW264.7 macrophages. We found [...] Read more.
Micrometam C is a core of novel marine compound isolated from the mangrove associates Micromelum falcatum. In this study, we investigated the protective effects of micrometam C in inflammation models in the transgenic zebrafish line Tg (corola: eGFP) and RAW264.7 macrophages. We found that micrometam C significantly suppressed the migration of immune cells in tail-cutting-induced inflammation in transgenic zebrafish and reduced lipopolysaccharide (LPS)-induced reactive oxygen species (ROS) in both zebrafish and macrophages. In addition, micrometam C also restored LPS-induced reduction of endogenous antioxidants, such as catalase (CAT), glutathione (GSH) and superoxide dismutase (SOD). The protective effects of micrometam C were in parallel to its inhibition of NADPH oxidase and nuclear factor-kappa-binding (NF-κB) activity. Thus, the present results demonstrate that micrometam C protects against LPS-induced inflammation possibly through its antioxidant property. Full article
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