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Keywords = microengineered physiological system (MPS)

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19 pages, 2636 KB  
Review
Advanced Fabrication Techniques of Microengineered Physiological Systems
by Joseph R. Puryear III, Jeong-Kee Yoon and YongTae Kim
Micromachines 2020, 11(8), 730; https://doi.org/10.3390/mi11080730 - 28 Jul 2020
Cited by 35 | Viewed by 5101
Abstract
The field of organs-on-chips (OOCs) has experienced tremendous growth over the last decade. However, the current main limiting factor for further growth lies in the fabrication techniques utilized to reproducibly create multiscale and multifunctional devices. Conventional methods of photolithography and etching remain less [...] Read more.
The field of organs-on-chips (OOCs) has experienced tremendous growth over the last decade. However, the current main limiting factor for further growth lies in the fabrication techniques utilized to reproducibly create multiscale and multifunctional devices. Conventional methods of photolithography and etching remain less useful to complex geometric conditions with high precision needed to manufacture the devices, while laser-induced methods have become an alternative for higher precision engineering yet remain costly. Meanwhile, soft lithography has become the foundation upon which OOCs are fabricated and newer methods including 3D printing and injection molding show great promise to innovate the way OOCs are fabricated. This review is focused on the advantages and disadvantages associated with the commonly used fabrication techniques applied to these microengineered physiological systems (MPS) and the obstacles that remain in the way of further innovation in the field. Full article
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