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Search Results (3)

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Keywords = mechano-bactericidal effect

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14 pages, 4480 KB  
Article
Calcium Phosphate (CaP) Composite Nanostructures on Polycaprolactone (PCL): Synergistic Effects on Antibacterial Activity and Osteoblast Behavior
by Suvd Erdene Ganbaatar, Hee-Kyeong Kim, Nae-Un Kang, Eun Chae Kim, Hye Jin U, Young-Sam Cho and Hyun-Ha Park
Polymers 2025, 17(2), 200; https://doi.org/10.3390/polym17020200 - 14 Jan 2025
Cited by 3 | Viewed by 1506
Abstract
Bone tissue engineering aims to develop biomaterials that are capable of effectively repairing and regenerating damaged bone tissue. Among the various polymers used in this field, polycaprolactone (PCL) is one of the most widely utilized. As a biocompatible polymer, PCL is easy to [...] Read more.
Bone tissue engineering aims to develop biomaterials that are capable of effectively repairing and regenerating damaged bone tissue. Among the various polymers used in this field, polycaprolactone (PCL) is one of the most widely utilized. As a biocompatible polymer, PCL is easy to fabricate, cost-effective, and offers consistent quality control, making it a popular choice for biomedical applications. However, PCL lacks inherent antibacterial properties, making it susceptible to bacterial adhesion and biofilm formation, which can lead to implant failure. To address this issue, this study aims to enhance the antibacterial properties of PCL by incorporating calcium phosphate composite (PCL_CaP) nanostructures onto its surface via hydrothermal synthesis. The resulting “PCL_CaP” nanostructured surfaces exhibited improved wettability and demonstrated mechano-bactericidal potential against Escherichia coli and Bacillus subtilis. The flake-like morphology of the fabricated CaP nanostructures effectively disrupted bacteria membranes, inhibiting bacterial growth. Furthermore, the “PCL_CaP” surfaces supported the adhesion, proliferation, and differentiation of pre-osteoblasts, indicating their potential for bone tissue engineering applications. This study demonstrates the promise of calcium phosphate composite nanostructures as an effective antibacterial coating for implants and medical devices, with further research required to evaluate their long-term stability and in vivo performance. Full article
(This article belongs to the Section Polymer Applications)
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34 pages, 5954 KB  
Review
Progress in Nanostructured Mechano-Bactericidal Polymeric Surfaces for Biomedical Applications
by S. P. S. N. Buddhika Sampath Kumara, S. W. M. Amal Ishantha Senevirathne, Asha Mathew, Laura Bray, Mohammad Mirkhalaf and Prasad K. D. V. Yarlagadda
Nanomaterials 2023, 13(20), 2799; https://doi.org/10.3390/nano13202799 - 20 Oct 2023
Cited by 10 | Viewed by 3559
Abstract
Bacterial infections and antibiotic resistance remain significant contributors to morbidity and mortality worldwide. Despite recent advances in biomedical research, a substantial number of medical devices and implants continue to be plagued by bacterial colonisation, resulting in severe consequences, including fatalities. The development of [...] Read more.
Bacterial infections and antibiotic resistance remain significant contributors to morbidity and mortality worldwide. Despite recent advances in biomedical research, a substantial number of medical devices and implants continue to be plagued by bacterial colonisation, resulting in severe consequences, including fatalities. The development of nanostructured surfaces with mechano-bactericidal properties has emerged as a promising solution to this problem. These surfaces employ a mechanical rupturing mechanism to lyse bacterial cells, effectively halting subsequent biofilm formation on various materials and, ultimately, thwarting bacterial infections. This review delves into the prevailing research progress within the realm of nanostructured mechano-bactericidal polymeric surfaces. It also investigates the diverse fabrication methods for developing nanostructured polymeric surfaces with mechano-bactericidal properties. We then discuss the significant challenges associated with each approach and identify research gaps that warrant exploration in future studies, emphasizing the potential for polymeric implants to leverage their distinct physical, chemical, and mechanical properties over traditional materials like metals. Full article
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25 pages, 2161 KB  
Review
Biomimetic Functional Surfaces towards Bactericidal Soft Contact Lenses
by Tianyu Mao and Fengzhou Fang
Micromachines 2020, 11(9), 835; https://doi.org/10.3390/mi11090835 - 31 Aug 2020
Cited by 11 | Viewed by 4648
Abstract
The surface with high-aspect-ratio nanostructure is observed to possess the bactericidal properties, where the physical interaction between high-aspect-ratio nanostructure could exert sufficient pressure on the cell membrane eventually lead to cell lysis. Recent studies in the interaction mechanism and reverse engineering have transferred [...] Read more.
The surface with high-aspect-ratio nanostructure is observed to possess the bactericidal properties, where the physical interaction between high-aspect-ratio nanostructure could exert sufficient pressure on the cell membrane eventually lead to cell lysis. Recent studies in the interaction mechanism and reverse engineering have transferred the bactericidal capability to artificial surface, but the biomimetic surfaces mimicking the topographical patterns on natural resources possess different geometrical parameters and surface properties. The review attempts to highlight the recent progress in bactericidal nanostructured surfaces to analyze the prominent influence factors and cell rupture mechanism. A holistic approach was utilized, integrating interaction mechanisms, material characterization, and fabrication techniques to establish inclusive insights into the topographical effect and mechano-bactericidal applications. The experimental work presented in the hydrogel material field provides support for the feasibility of potentially broadening applications in soft contact lenses. Full article
(This article belongs to the Special Issue Top-Down Micro- or Nanofabrication and Its Applications)
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