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Keywords = magnetic microbot

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8 pages, 877 KiB  
Article
Rolling Motion of a Soft Microsnowman under Rotating Magnetic Field
by Gokhan Kararsiz, Yasin Cagatay Duygu, Louis William Rogowski, Anuruddha Bhattacharjee and Min Jun Kim
Micromachines 2022, 13(7), 1005; https://doi.org/10.3390/mi13071005 - 26 Jun 2022
Cited by 8 | Viewed by 3275
Abstract
This paper demonstrates a manipulation of snowman-shaped soft microrobots under a uniform rotating magnetic field. Each microsnowman robot consists of two biocompatible alginate microspheres with embedded magnetic nanoparticles. The soft microsnowmen were fabricated using a microfluidic device by following a centrifuge-based microfluidic droplet [...] Read more.
This paper demonstrates a manipulation of snowman-shaped soft microrobots under a uniform rotating magnetic field. Each microsnowman robot consists of two biocompatible alginate microspheres with embedded magnetic nanoparticles. The soft microsnowmen were fabricated using a microfluidic device by following a centrifuge-based microfluidic droplet method. Under a uniform rotating magnetic field, the microsnowmen were rolled on the substrate surface, and the velocity response for increasing magnetic field frequencies was analyzed. Then, a microsnowman was rolled to follow different paths, which demonstrated directional controllability of the microrobot. Moreover, swarms of microsnowmen and single alginate microrobots were manipulated under the rotating magnetic field, and their velocity responses were analyzed for comparison. Full article
(This article belongs to the Special Issue Magnetic Manipulation of Micro/Nano Objects)
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12 pages, 2657 KiB  
Article
Microbots Gene Delivery System Based on Bifidobacteria in a Tumor Model
by Luis D. Terrazas Armendáriz, Itza E. Luna Cruz, Cynthia A. Alvizo Báez, Azael A. Cavazos Jaramillo, Cristina Rodríguez Padilla, Reyes S. Tamez-Guerra and Juan M. Alcocer González
Appl. Sci. 2021, 11(12), 5544; https://doi.org/10.3390/app11125544 - 15 Jun 2021
Cited by 2 | Viewed by 2580
Abstract
In cancer, the use of microbots based on anaerobic bacteria as specific transporters targeting tumor tissues has been explored since most solid tumors exhibit hypoxic regions. The aim of this study was to develop and characterize magnetic microbots based on Bifidobacteria and iron [...] Read more.
In cancer, the use of microbots based on anaerobic bacteria as specific transporters targeting tumor tissues has been explored since most solid tumors exhibit hypoxic regions. The aim of this study was to develop and characterize magnetic microbots based on Bifidobacteria and iron oxide fluorescent magnetic nanoparticles complexed with chitosan and a hypoxia inducible plasmid. In addition, the efficiency of the microbots for gene delivery to solid tumors was evaluated in an in vivo model by florescence and luminescence. To elaborate microbots, iron oxide fluorescent magnetic nanoparticles complexed with chitosan and a hypoxia-inducible plasmid called nanocomplex (NCs) with a size of 302 nm and a ζ potential of +16 mV were obtained and loaded onto Bifidobacteria membranes. Microbots with a diameter between 1–2 µm were characterized by atomic force microscopy (AFM) and scanning electron microscopy (SEM). Microbots were injected intravenously through the tail vein to tumor-bearing mice, and then a magnet was placed to focus them to the tumor area. Forty-eight hours after injection, the biodistribution was determined by florescence and luminescence. The greatest luminescence and fluorescence emitted were found in tumor tissue compared with the normal organs. We created a vector that can be directed by a magnet and deliver genes whose expression is regulated by hypoxic microenvironment of tumor. Full article
(This article belongs to the Section Applied Biosciences and Bioengineering)
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