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Keywords = jaspamide Q and R

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Article
Two New Jaspamide Derivatives from the Marine Sponge Jaspis splendens
by Sherif S. Ebada, Victor Wray, Nicole J. De Voogd, Zhiwei Deng, Wenhan Lin and Peter Proksch
Mar. Drugs 2009, 7(3), 435-444; https://doi.org/10.3390/md7030435 - 15 Sep 2009
Cited by 41 | Viewed by 14231
Abstract
Two new jaspamide derivatives 2 and 3, together with the parent compound jaspamide (1) have been isolated from the marine sponge Jaspis splendens collected in Kalimantan (Indonesia). The structures of the new compounds were unambiguously elucidated based on 1D and 2D NMR spectral [...] Read more.
Two new jaspamide derivatives 2 and 3, together with the parent compound jaspamide (1) have been isolated from the marine sponge Jaspis splendens collected in Kalimantan (Indonesia). The structures of the new compounds were unambiguously elucidated based on 1D and 2D NMR spectral data, mass spectrometry and comparison with jaspamide (1). The new derivatives inhibited the growth of mouse lymphoma (L5178Y) cell line in vitro with IC50 values of <0.1 μg/mL. Full article
(This article belongs to the Special Issue Bioactive Compound from Marine Sponges)
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