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Keywords = iron oxide nanorod particles

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16 pages, 6463 KiB  
Article
Decaying Oscillating Pulsed Magnetic Field Induces Lysosome-Dependent Cell Death in A375 Melanoma via Magneto-Mechanical Force
by Yan Mi, Jianli Wang, Sifan Tang, Chi Ma, Wei Zheng and Jiayu Chen
Magnetochemistry 2025, 11(4), 33; https://doi.org/10.3390/magnetochemistry11040033 - 14 Apr 2025
Viewed by 976
Abstract
The synergistic application of magnetic fields and iron oxide nanorod particles (IONPs) presents a novel therapeutic approach for inducing lysosome-dependent cell death (LDCL) via magneto-mechanical force (MMF). This study demonstrates the efficacy of decaying oscillating pulsed magnetic fields (DOPMFs) to propel IONPs to [...] Read more.
The synergistic application of magnetic fields and iron oxide nanorod particles (IONPs) presents a novel therapeutic approach for inducing lysosome-dependent cell death (LDCL) via magneto-mechanical force (MMF). This study demonstrates the efficacy of decaying oscillating pulsed magnetic fields (DOPMFs) to propel IONPs to induce rapid tumor regression via lysosomal membrane permeabilization (LMP). The systematic evaluation of dose-dependent parameters revealed that DOPMF intensity and pulse number critically determine A375 melanoma cell viability reduction. Mechanistic investigations identified two hallmark biomarkers of LMP: increased cytosolic cathepsin B activity and downregulated LAMP-2 expression. Crucially, in vivo experiments using A375 melanoma-bearing mouse models corroborated the therapeutic potential of this approach, showing significant tumor growth inhibition without systemic toxicity or invasive procedures. Collectively, our findings demonstrate that MMF by IONPs under DOPMF stimulation exhibits significant efficacy in suppressing melanoma proliferation, offering a non-invasive, targeted approach for oncological intervention. Full article
(This article belongs to the Section Applications of Magnetism and Magnetic Materials)
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11 pages, 6906 KiB  
Article
Goethite Nanorods: Synthesis and Investigation of the Size Effect on Their Orientation within a Magnetic Field by SAXS
by Stephan Hinrichs, Larissa Grossmann, Eike Clasen, Hannah Grotian genannt Klages, Dieter Skroblin, Christian Gollwitzer, Andreas Meyer and Birgit Hankiewicz
Nanomaterials 2020, 10(12), 2526; https://doi.org/10.3390/nano10122526 - 16 Dec 2020
Cited by 12 | Viewed by 3257
Abstract
Goethite is a naturally anisotropic, antiferromagnetic iron oxide. Following its atomic structure, crystals grow into a fine needle shape that has interesting properties in a magnetic field. The needles align parallel to weak magnetic fields and perpendicular when subjected to high fields. We [...] Read more.
Goethite is a naturally anisotropic, antiferromagnetic iron oxide. Following its atomic structure, crystals grow into a fine needle shape that has interesting properties in a magnetic field. The needles align parallel to weak magnetic fields and perpendicular when subjected to high fields. We synthesized goethite nanorods with lengths between 200 nm and 650 nm in a two-step process. In a first step we synthesized precursor particles made of akaganeite (β-FeOOH) rods from iron(III)chloride. The precursors were then treated in a hydrothermal reactor under alkaline conditions with NaOH and polyvinylpyrrolidone (PVP) to form goethite needles. The aspect ratio was tunable between 8 and 15, based on the conditions during hydrothermal treatment. The orientation of these particles in a magnetic field was investigated by small angle X-ray scattering (SAXS). We observed that the field strength required to trigger a reorientation is dependent on the length and aspect ratio of the particles and could be shifted from 85 mT for the small particles to about 147 mT for the large particles. These particles could provide highly interesting magnetic properties to nanocomposites, that could then be used for sensing applications or membranes. Full article
(This article belongs to the Section Synthesis, Interfaces and Nanostructures)
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