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Keywords = intraperitoneal free cancer cells (IFCCs)

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45 pages, 3266 KiB  
Review
Peritoneal Metastasis: A Dilemma and Challenge in the Treatment of Metastatic Colorectal Cancer
by Wei Xia, Yiting Geng and Wenwei Hu
Cancers 2023, 15(23), 5641; https://doi.org/10.3390/cancers15235641 - 29 Nov 2023
Cited by 15 | Viewed by 6808
Abstract
Peritoneal metastasis (PM) is a common mode of distant metastasis in colorectal cancer (CRC) and has a poorer prognosis compared to other metastatic sites. The formation of PM foci depends on the synergistic effect of multiple molecules and the modulation of various components [...] Read more.
Peritoneal metastasis (PM) is a common mode of distant metastasis in colorectal cancer (CRC) and has a poorer prognosis compared to other metastatic sites. The formation of PM foci depends on the synergistic effect of multiple molecules and the modulation of various components of the tumor microenvironment. The current treatment of CRC-PM is based on systemic chemotherapy. However, recent developments in local therapeutic modalities, such as cytoreductive surgery (CRS) and intraperitoneal chemotherapy (IPC), have improved the survival of these patients. This article reviews the research progress on the mechanism, characteristics, diagnosis, and treatment strategies of CRC-PM, and discusses the current challenges, so as to deepen the understanding of CRC-PM among clinicians. Full article
(This article belongs to the Section Cancer Metastasis)
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