Search Results (4)

Permanent engravings on contact lenses provide information about the manufacturing process and lens positioning when they are placed on the eye. The inspection of their morphological characteristics is important, since they can affect the user’s comfort and deposit adhesion. Therefore, an inverted wavefront holoscope (a lensless microscope based on Gabor’s principle of in-line digital holography) is explored for the characterization of the permanent marks of soft contact lenses. The device, based on an in-line transmission configuration, uses a partially coherent laser source to illuminate the soft contact lens placed in a cuvette filled with a saline solution for lens preservation. Holograms were recorded on a digital sensor and reconstructed by back propagation to the image plane based on the angular spectrum method. In addition, a phase-retrieval algorithm was used to enhance the quality of the recovered images. The instrument was experimentally validated through a calibration process in terms of spatial resolution and thickness estimation, showing values that perfectly agree with those that were theoretically expected. Finally, phase maps of different engravings for three commercial soft contact lenses were successfully reconstructed, validating the inverted wavefront holoscope as a potential instrument for the characterization of the permanent marks of soft contact lenses. To improve the final image quality of reconstructions, the geometry of lenses should be considered to avoid induced aberration effects. Full article

In this paper, a method is described to perform ion concentration measurements on both sides of an inserted contact lens, without physical contact with the eye or the contact lens. The outer surface of an eye is covered with a tear film that has multiple layers. The central aqueous layer contains electrolytes and proteins. When a contact lens is inserted, it becomes localized in the central layer, which creates two layers known as the pre-lens tear film (PLTF) and the post-lens tear film (PoLTF). The PoLTF is in direct contact with the sensitive corneal epithelial cells which control electrolyte concentrations in tears. It is difficult to measure the overall electrolyte concentration in tears because of the small 7 μL volume of bulk tears. No methods are known, and no method has been proposed, to selectively measure the concentrations of electrolytes in the smaller volumes of the PLTF and the PoLTF. In this paper, we demonstrate the ability to localize fluorophores on each side of a contact lens without probe mixing or diffusion across the lens. We measured the concentration of sodium in the region of the PoLTF using a sodium-sensitive fluorophore positioned on the inner surface of a contact lens. The fluorescence measurements do not require physical contact and are mostly independent of eye motion and fluorophore concentration. The method is generic and can be combined with ion-sensitive fluorophores for the other electrolytes in tears. Instrumentation for non-contact measurements is likely to be inexpensive with modern opto-electronic devices. We expect these lenses to be used for measurements of other ions in the PLTF and the PoLTF, and thus become useful for both research and in the diagnosis of infections, keratitis and biomarkers for diseases. Full article

The focus of this study is to design a backlit vision instrument capable of measuring surface roughness and to discuss its metrological performance compared to traditional measurement instruments. The instrument is a non-contact high-magnification imaging system characterized by short inspection time which opens the perspective of in-line implementation. We combined the use of the modulation transfer function to evaluate the imaging conditions of an electrically tunable lens to obtain an optimally focused image. We prepared a set of turned steel samples with different roughness in the range R_a 2.4 µm to 15.1 µm. The layout of the instrument is presented, including a discussion on how optimal imaging conditions were obtained. The paper describes the comparison performed on measurements collected with the vision system designed in this work and state-of-the-art instruments. A comparison of the results of the backlit system depends on the values of surface roughness considered; while at larger values of roughness the offset increases, the results are compatible with the ones of the stylus at lower values of roughness. In fact, the error bands are superimposed by at least 58% based on the cases analyzed. Full article

We present the design, fabrication, and test of a multipurpose integrated circuit (Application Specific Integrated Circuit) in AMS 0.35 µm Complementary Metal Oxide Semiconductor technology. This circuit is embedded in a scleral contact lens, combined with photodiodes enabling the gaze direction detection when illuminated and wirelessly powered by an eyewear. The gaze direction is determined by means of a centroid computation from the measured photocurrents. The ASIC is used simultaneously to detect specific eye blinking sequences to validate target designations, for instance. Experimental measurements and validation are performed on a scleral contact lens prototype integrating four infrared photodiodes, mounted on a mock-up eyeball, and combined with an artificial eyelid. The eye-tracker has an accuracy of 0.2°, i.e., 2.5 times better than current mobile video-based eye-trackers, and is robust with respect to process variations, operating time, and supply voltage. Variations of the computed gaze direction transmitted to the eyewear, when the eyelid moves, are detected and can be interpreted as commands based on blink duration or using blinks alternation on both eyes. Full article