Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline
remove_circle_outline

Journals

Article Types

Countries / Regions

Search Results (1)

Search Parameters:
Keywords = immunophage synergy

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
12 pages, 14902 KiB  
Article
A Combination of Virulent and Non-Productive Phages Synergizes the Immune System against Salmonella Typhimurium Systemic Infection
by Lu Liang, Jiaqi Huang, Ketong Cui, Peiyong Li, Wenjian Shi, Fang Lin, Guijuan Hao and Shuhong Sun
Int. J. Mol. Sci. 2022, 23(21), 12830; https://doi.org/10.3390/ijms232112830 - 24 Oct 2022
Cited by 5 | Viewed by 2380
Abstract
Effective phage cocktails consisting of multiple virus types are essential for successful phage therapy against pandrug-resistant pathogens, including Salmonella enterica serovar (S.) Typhimurium. Here we show that a Salmonella phage, F118P13, with non-productive infection and a lytic phage, PLL1, combined to [...] Read more.
Effective phage cocktails consisting of multiple virus types are essential for successful phage therapy against pandrug-resistant pathogens, including Salmonella enterica serovar (S.) Typhimurium. Here we show that a Salmonella phage, F118P13, with non-productive infection and a lytic phage, PLL1, combined to inhibit pandrug-resistant S. Typhimurium growth and significantly limited resistance to phages in vitro. Further, intraperitoneal injection with this unique phage combination completely protected mice from Salmonella-induced death and inhibited bacterial proliferation rapidly in various organs. Furthermore, the phage combination treatment significantly attenuated the inflammatory response, restored the generation of CD4+ T cells repressed by Salmonella, and allowed macrophages and granulocytes to participate in immunophage synergy to promote bacterial clearance. Crucially, the non-productive phage F118P13 is less likely to be cleared by the immune system in vivo, thus providing an alternative to phage cocktail against bacterial infections. Full article
(This article belongs to the Special Issue Bacteriophage—Molecular Studies 4.0)
Show Figures

Figure 1

Back to TopTop