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This investigation attempts to develop a tower solar collector-based system designed for the cogeneration of cooling and desalination. The traditional organic Rankine cycle (ORC) integrated with the ejector refrigeration cycle generates limited power and cooling at a single temperature. Acknowledging their limitations, our present study uses an organic flash cycle (OFC) supported by solar heat combined with the two-phase ejector cycle and the reverse osmosis (RO) desalination unit. Since the OFC turbine is fed with two extra streams of fluid, therefore, it provides greater power to run the compressor of the ejector and pumps of the RO unit, resulting in the production of cooling at two different temperatures (refrigeration and air conditioning) and a higher mass flow rate of fresh water. A mathematical model is employed to assess the impact of coil curvature ratio, Rib height, and direct normal irradiation (DNI) on the temperature of the collector’s oil outlet. ANSYS-FLUENT conducts numerical simulations through computational fluid dynamics (CFD) analysis. The results indicate an ultimate increase in oil outlet temperature of 45% as the DNI increased from 450 to 1000 W/m² at a curvature ratio of 0.095 when employing the 1st Rib. Further, a steady-state energy and exergy analysis is conducted to evaluate the performance of the proposed cogeneration, with different design parameters like DNI, coil curvature ratio, rib height, and OFC turbine inlet pressure. The energetic and exergetic efficiencies of the cogeneration system at DNI of 800 W/m² are obtained as 16.67% and 6.08%, respectively. Exergetic assessment of the overall system shows that 29.57% is the exergy produced as cooling exergy, and the exergy accompanied by freshwater, 68.13%, is the exergy destroyed, and 2.3% is the exergy loss. The solar collector exhibits the maximum exergy destruction, followed by the ejector and RO pumps. Integrating multiple technologies into a system with solar input enhances efficiency, energy sustainability, and environmental benefits. Full article