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Keywords = fermented Houttuynia cordata juice

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16 pages, 3109 KiB  
Article
Fermented Houttuynia cordata Juice Exerts Cardioprotective Effects by Alleviating Cardiac Inflammation and Apoptosis in Rats with Lipopolysaccharide-Induced Sepsis
by Natticha Sumneang, Anongporn Kobroob, Sukanya Phungphong, Worakan Boonhoh, Chuchard Punsawad and Napapan Kangwan
Nutrients 2025, 17(3), 501; https://doi.org/10.3390/nu17030501 - 29 Jan 2025
Cited by 1 | Viewed by 1633
Abstract
Background/Objectives: Sepsis-induced cardiac dysfunction is a major problem that often leads to severe complications and a poor prognosis. Despite the growing awareness of its impact, effective treatment options for sepsis-induced cardiac dysfunction remain limited. To date, fermented products of Houttuynia cordata (HC), known [...] Read more.
Background/Objectives: Sepsis-induced cardiac dysfunction is a major problem that often leads to severe complications and a poor prognosis. Despite the growing awareness of its impact, effective treatment options for sepsis-induced cardiac dysfunction remain limited. To date, fermented products of Houttuynia cordata (HC), known for its rich bioactive properties, have shown potential in modulating inflammatory and oxidative stress pathways. However, treatment with fermented HC juice (FHJ) in lipopolysaccharide (LPS)-induced sepsis in rats has not been investigated. Methods: Rats were pretreated with FHJ at doses of 200 mg/kg and 400 mg/kg for 2 weeks. After that, the rats were injected with a single dose of LPS (10 mg/kg), and 12 h after injection, they developed sepsis-induced cardiac dysfunction. Then, cardiac function, oxidative stress, inflammation, apoptosis, and cardiac injury markers were determined. Results: Pretreatment with FHJ at doses of 200 mg/kg and 400 mg/kg prevented LPS-induced cardiac dysfunction in rats by attenuating cardiac inflammation (IL-1β, TLR-4, and NF-κB levels), oxidative stress (MDA levels), and apoptosis (cleaved-caspase 3 and Bax/Bcl-2 expression) and reducing markers of cardiac injury (LDH and CK-MB levels). Conclusions: These results suggest that FHJ could be a potential therapeutic agent for sepsis-induced heart disease. Full article
(This article belongs to the Special Issue Anti-Inflammatory, Antioxidant, and Antimicrobial Potential of Natural Products)
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