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Article

10 Citations

4,322 Views

16 Pages

The Effect of Super-Repressor IkB-Loaded Exosomes (Exo-srIκBs) in Chronic Post-Ischemia Pain (CPIP) Models

Ji Seon Chae,
Hyunju Park,
So-Hee Ahn,
Eun-Chong Han,
Yoonjin Lee,
Youn Jin Kim,
Eun-Jin Ahn,
Hye-Won Oh,
Hyun Jung Lee and
Won-joong Kim
+ 2 authors

Pharmaceutics2023, 15(2), 553;https://doi.org/10.3390/pharmaceutics15020553

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7 February 2023

Complex regional pain syndrome (CRPS) is a condition associated with neuropathic pain that causes significant impairment of daily activities and functioning. Nuclear factor kappa B (NFκB) is thought to play an important role in the mechanism of...

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Article

1,744 Views

14 Pages

Engineered Exosomes Carrying Super-Repressor IκB Reduced Biliary Atresia-Induced Liver Fibrosis in Minipig and Mouse Models

Jisoo Kang,
Cheolhyoung Park,
Hanoul Yun,
Chulhee Choi and
Wonhyo Seo

Pharmaceutics2025, 17(2), 264;https://doi.org/10.3390/pharmaceutics17020264

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17 February 2025

Background and Aim: Biliary atresia is a rare, progressive disease that affects the bile ducts in newborns. Persistent bile duct obstruction induces various pathological conditions, including jaundice, inflammation, and liver fibrosis; however, the e...

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Article

14 Citations

4,689 Views

18 Pages

Exosome-Based Delivery of Super-Repressor IκBα Alleviates Alcohol-Associated Liver Injury in Mice

Hee-Hoon Kim,
Young-Ri Shim,
Sung Eun Choi,
Tolulope Esther Falana,
Jae-Kwang Yoo,
So-Hee Ahn,
Minhye Park,
Hyangmi Seo,
Chulhee Choi and
Won-Il Jeong

Pharmaceutics2023, 15(2), 636;https://doi.org/10.3390/pharmaceutics15020636

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14 February 2023

Activation of Kupffer cells (KCs) by gut-derived lipopolysaccharide (LPS) instigates nuclear factor-κB (NF-κB)-mediated inflammatory responses in alcohol-associated liver diseases (ALD). Here, we utilized a novel optogenetically engineere...

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