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Search Results (3)

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Keywords = exhaled hydrogen sulfide

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29 pages, 1134 KiB  
Review
Exhaled Biomarkers for Point-of-Care Diagnosis: Recent Advances and New Challenges in Breathomics
by Helga Kiss, Zoltán Örlős, Áron Gellért, Zsolt Megyesfalvi, Angéla Mikáczó, Anna Sárközi, Attila Vaskó, Zsuzsanna Miklós and Ildikó Horváth
Micromachines 2023, 14(2), 391; https://doi.org/10.3390/mi14020391 - 4 Feb 2023
Cited by 19 | Viewed by 6400
Abstract
Cancers, chronic diseases and respiratory infections are major causes of mortality and present diagnostic and therapeutic challenges for health care. There is an unmet medical need for non-invasive, easy-to-use biomarkers for the early diagnosis, phenotyping, predicting and monitoring of the therapeutic responses of [...] Read more.
Cancers, chronic diseases and respiratory infections are major causes of mortality and present diagnostic and therapeutic challenges for health care. There is an unmet medical need for non-invasive, easy-to-use biomarkers for the early diagnosis, phenotyping, predicting and monitoring of the therapeutic responses of these disorders. Exhaled breath sampling is an attractive choice that has gained attention in recent years. Exhaled nitric oxide measurement used as a predictive biomarker of the response to anti-eosinophil therapy in severe asthma has paved the way for other exhaled breath biomarkers. Advances in laser and nanosensor technologies and spectrometry together with widespread use of algorithms and artificial intelligence have facilitated research on volatile organic compounds and artificial olfaction systems to develop new exhaled biomarkers. We aim to provide an overview of the recent advances in and challenges of exhaled biomarker measurements with an emphasis on the applicability of their measurement as a non-invasive, point-of-care diagnostic and monitoring tool. Full article
(This article belongs to the Special Issue Microfluidics and Biosensors for Point-of-Care Applications)
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10 pages, 1213 KiB  
Article
A Low-Cost Device for Measurement of Exhaled Breath for the Detection of Obstructive Lung Disease
by Adil Ahmad Shahzad, Shafaq Mushtaq, Asim Waris, Syed Omer Gilani, Maha Abdallah Alnuwaiser, Mohammed Jameel and Niaz Bahadur Khan
Biosensors 2022, 12(6), 409; https://doi.org/10.3390/bios12060409 - 13 Jun 2022
Cited by 13 | Viewed by 3971
Abstract
Breath sensor technology can be used in medical diagnostics. This study aimed to build a device to measure the level of hydrogen sulfide, ammonia, acetone and alcohol in exhaled breath of patients as well as healthy individuals. The purpose was to determine the [...] Read more.
Breath sensor technology can be used in medical diagnostics. This study aimed to build a device to measure the level of hydrogen sulfide, ammonia, acetone and alcohol in exhaled breath of patients as well as healthy individuals. The purpose was to determine the efficacy of these gases for detection of obstructive lung disease. This study was conducted on a total of 105 subjects, where 60 subjects were patients of obstructive lung disease and 45 subjects were healthy individuals. Patients were screened by means of the Pulmonary Function Test (PFT) by a pulmonologist. The gases present in the exhaled breath of all subjects were measured. The level of ammonia (32.29 ± 20.83 ppb), (68.83 ± 35.25 ppb), hydrogen sulfide (0.50 ± 0.26 ppm), (62.71 ± 22.20 ppb), and acetone (103.49 ± 35.01 ppb), (0.66 ± 0.31 ppm) in exhaled breath were significantly different (p < 0.05) between obstructive lung disease patients and healthy individuals, except alcohol, with a p-value greater than 0.05. Positive correlation was found between ammonia w.r.t Forced Expiratory Volume in 1 s (FEV1) (r = 0.74), Forced Vital Capacity (FVC) (r = 0.61) and Forced Expiratory Flow (FEF) (r = 0.63) and hydrogen sulfide w.r.t FEV1 (r = 0.54), FVC (r = 0.41) and FEF (r = 0.37). Whereas, weak correlation was found for acetone and alcohol w.r.t FEV1, FVC and PEF. Therefore, the level of ammonia and hydrogen sulfide are useful breath markers for detection of obstructive lung disease. Full article
(This article belongs to the Special Issue Novel Biosensors as the Key Enablers for Telemedicine Revolution to Combat COVID-19)
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19 pages, 1917 KiB  
Review
The Use of Copper Oxide Thin Films in Gas-Sensing Applications
by Artur Rydosz
Coatings 2018, 8(12), 425; https://doi.org/10.3390/coatings8120425 - 26 Nov 2018
Cited by 131 | Viewed by 12063
Abstract
In this work, the latest achievements in the field of copper oxide thin film gas sensors are presented and discussed. Several methods and deposition techniques are shown with their advantages and disadvantages for commercial applications. Recently, CuO thin film gas sensors have been [...] Read more.
In this work, the latest achievements in the field of copper oxide thin film gas sensors are presented and discussed. Several methods and deposition techniques are shown with their advantages and disadvantages for commercial applications. Recently, CuO thin film gas sensors have been studied to detect various compounds, such as: nitrogen oxides, carbon oxides, hydrogen sulfide, ammonia, as well as several volatile organic compounds in many different applications, e.g., agriculture. The CuO thin film gas sensors exhibited high 3-S parameters (sensitivity, selectivity, and stability). Furthermore, the possibility to function at room temperature with long-term stability was proven as well, which makes this material very attractive in gas-sensing applications, including exhaled breath analysis. Full article
(This article belongs to the Special Issue Thin Films for Electronic Applications)
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