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Keywords = erythromycin thiocyanate dihydrate

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17 pages, 1325 KB  
Article
Thermodynamic Behavior of Erythromycin Thiocyanate Dihydrate in Six Pure Solvents and Two Binary Solvents
by Jin Feng, Xunhui Li, Lianjie Zhai, Peizhou Li, Ting Qin, Na Wang, Lu Zhou, Baoxin Zhang, Ting Wang, Xin Huang and Hongxun Hao
Molecules 2025, 30(11), 2424; https://doi.org/10.3390/molecules30112424 - 31 May 2025
Cited by 1 | Viewed by 917
Abstract
Thermodynamic parameters play a crucial role in analyzing and optimizing crystallization processes. In this investigation, the solubility profiles of erythromycin thiocyanate dihydrate were determined gravimetrically under atmospheric pressure (0.1 MPa) across six monosolvent systems (methanol, n-propanol, methyl acetate, ethyl acetate, propyl acetate, and [...] Read more.
Thermodynamic parameters play a crucial role in analyzing and optimizing crystallization processes. In this investigation, the solubility profiles of erythromycin thiocyanate dihydrate were determined gravimetrically under atmospheric pressure (0.1 MPa) across six monosolvent systems (methanol, n-propanol, methyl acetate, ethyl acetate, propyl acetate, and water) and two binary solvent mixtures (water–methanol and water–n-propanol), spanning a temperature range of 278.15–318.15 K. The results showed that the solubility of erythromycin thiocyanate dihydrate is apparently affected by temperature and solvent type. For pure solvents, erythromycin thiocyanate dihydrate has higher solubility in alcohol solvents, and lower solubility in ester solvents and water. In mixed solvent systems, erythromycin thiocyanate dihydrate exhibits reduced solubility with higher water content. The experimental solubility values in monosolvent systems were correlated using the Apelblat, Yaws, and Van’t Hoff models, with the Apelblat model showing the best fitting effect. The Apelblat model, Apelblat Jouyban Acre model, and CNIBS/R-K model were employed for data correlation in binary solvent systems, with the Apelblat model and CNIBS/R-K model showing better fitting results. Full article
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