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Keywords = endogenous angioinhibitors

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27 pages, 789 KiB  
Review
Proteolytically Derived Endogenous Angioinhibitors Originating from the Extracellular Matrix
by Chandra Shekhar Boosani and Yakkanti A. Sudhakar
Pharmaceuticals 2011, 4(12), 1551-1577; https://doi.org/10.3390/ph4121551 - 2 Dec 2011
Cited by 17 | Viewed by 8914
Abstract
Angiogenesis, a neovascularization process induced from the existing parent blood vessels, is a prerequisite for many physiological and pathological conditions. Under physiological conditions it is regulated by a balance between endogenous angioinhibitors and angioactivators, and an imbalance between them would lead to pathological [...] Read more.
Angiogenesis, a neovascularization process induced from the existing parent blood vessels, is a prerequisite for many physiological and pathological conditions. Under physiological conditions it is regulated by a balance between endogenous angioinhibitors and angioactivators, and an imbalance between them would lead to pathological conditions such as cancer, age-related macular degeneration (AMD), diabetic retinopathy, cardiovascular diseases, etc. Several proteolytically generated endogenous molecules have been identified which exhibit angioinhibition and/or antitumor activities. These angioinhibitors interact with endothelial and tumor cells by binding to distinct integrins and initiate many of their intracellular signaling mechanisms regulating the cell survival and or apoptotic pathways. The present review will focus on the extracellular matrix derived angioinhibitors, and their mechanisms of actions that point to the clinical significance and therapeutic implications. Full article
(This article belongs to the Special Issue Angiogenesis Inhibitors)
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