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Keywords = end-to-side coaptation

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17 pages, 2290 KB  
Review
Molecular Basis of Surgical Coaptation Techniques in Peripheral Nerve Injuries
by Clifford T. Pereira, Elise E. Hill, Anastasiya Stasyuk, Neil Parikh, Jannat Dhillon, Aijun Wang and Andrew Li
J. Clin. Med. 2023, 12(4), 1555; https://doi.org/10.3390/jcm12041555 - 16 Feb 2023
Cited by 11 | Viewed by 3723
Abstract
Peripheral nerve injuries requiring surgical repair affect over 100,000 individuals in the US annually. Three accepted methods of peripheral repair include end-to-end, end-to-side, and side-to-side neurorrhaphy, each with its own set of indications. While it remains important to understand the specific circumstances in [...] Read more.
Peripheral nerve injuries requiring surgical repair affect over 100,000 individuals in the US annually. Three accepted methods of peripheral repair include end-to-end, end-to-side, and side-to-side neurorrhaphy, each with its own set of indications. While it remains important to understand the specific circumstances in which each method is employed, a deeper understanding of the molecular mechanisms underlying the repair can add to the surgeon’s decision-making algorithm when considering each technique, as well as help decide nuances in technique such as the need for making epineurial versus perineurial windows, length and dept of the nerve window, and distance from target muscle. In addition, a thorough knowledge of individual factors that are active in a particular repair can help guide research into adjunct therapies. This paper serves to summarize the similarities and divergences of the three commonly used nerve repair strategies and the scope of molecular mechanisms and signal transduction pathways in nerve regeneration as well as to identify the gaps in knowledge that should be addressed if we are to improve clinical outcomes in our patients. Full article
(This article belongs to the Special Issue Clinical Frontiers in Nerve Repair and Regeneration)
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17 pages, 2152 KB  
Systematic Review
The Grasping Test Revisited: A Systematic Review of Functional Recovery in Rat Models of Median Nerve Injury
by Henrik Lauer, Cosima Prahm, Johannes Tobias Thiel, Jonas Kolbenschlag, Adrien Daigeler, David Hercher and Johannes C. Heinzel
Biomedicines 2022, 10(8), 1878; https://doi.org/10.3390/biomedicines10081878 - 3 Aug 2022
Cited by 6 | Viewed by 4091
Abstract
The rat median nerve model is a well-established and frequently used model for peripheral nerve injury and repair. The grasping test is the gold-standard to evaluate functional recovery in this model. However, no comprehensive review exists to summarize the course of functional recovery [...] Read more.
The rat median nerve model is a well-established and frequently used model for peripheral nerve injury and repair. The grasping test is the gold-standard to evaluate functional recovery in this model. However, no comprehensive review exists to summarize the course of functional recovery in regard to the lesion type. According to PRISMA-guidelines, research was performed, including the databases PubMed and Web of Science. Groups were: (1) crush injury, (2) transection with end-to-end or with (3) end-to-side coaptation and (4) isogenic or acellular allogenic grafting. Total and respective number, as well as rat strain, type of nerve defect, length of isogenic or acellular allogenic allografts, time at first signs of motor recovery (FSR) and maximal recovery grasping strength (MRGS), were evaluated. In total, 47 articles met the inclusion criteria. Group I showed earliest signs of motor recovery. Slow recovery was observable in group III and in graft length above 25 mm. Isografts recovered faster compared to other grafts. The onset and course of recovery is heavily dependent from the type of nerve injury. The grasping test should be used complementary in addition to other volitional and non-volitional tests. Repetitive examinations should be planned carefully to optimize assessment of valid and reliable data. Full article
(This article belongs to the Special Issue Advanced Research in Peripheral Nerve Regeneration)
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