Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline

Journals

Article Types

Countries / Regions

Search Results (1)

Search Parameters:
Keywords = dicalcium phosphate anhydride

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
15 pages, 6418 KiB  
Article
Antimicrobial Activity of Protamine-Loaded Calcium Phosphates against Oral Bacteria
by Masashi Fujiki, Kodai Abe, Tohru Hayakawa, Takatsugu Yamamoto, Mana Torii, Keishi Iohara, Daisuke Koizumi, Rie Togawa, Mamoru Aizawa and Michiyo Honda
Materials 2019, 12(17), 2816; https://doi.org/10.3390/ma12172816 - 2 Sep 2019
Cited by 8 | Viewed by 3348
Abstract
Protamine is an antimicrobial peptide extracted from fish. In this study, we loaded protamine onto dicalcium phosphate anhydride (DCPA), a dental material. Protamine was loaded by stirring DCPA into a protamine solution. To explore the antimicrobial activity of the materials, we cultivated Streptococcus [...] Read more.
Protamine is an antimicrobial peptide extracted from fish. In this study, we loaded protamine onto dicalcium phosphate anhydride (DCPA), a dental material. Protamine was loaded by stirring DCPA into a protamine solution. To explore the antimicrobial activity of the materials, we cultivated Streptococcus mutans on fabricated discs for 24 h. When S. mutans was cultivated on the discs under no sucrose conditions, the loaded protamine was not released, and the ratio of dead bacteria increased on the surface of P (125) DCPA (half of the saturated level of protamine (125 ppm protamine) was loaded). Aside from P (500) DCPA (saturated level of protamine was loaded), some protamine was released, and the number of planktonic bacteria in the supernatant decreased. Using medium containing 1% sucrose, the release of protamine was promoted from P (125) DCPA due to lowered pH. However, lowering of the pH decreased the antimicrobial activity of protamine. On the other hand, P (500) DCPA released protamine before the pH was lowered, and biofilm formation was inhibited. The loaded protamine expressed antimicrobial activity, both on the surface of the materials and in the surrounding environment. The interaction of loaded protamine with calcium phosphates could promote the application of protamine in the dental field. Full article
(This article belongs to the Section Biomaterials)
Show Figures

Figure 1

Back to TopTop