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Keywords = deoxyenhygrolides

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15 pages, 2461 KiB  
Article
New Deoxyenhygrolides from Plesiocystis pacifica Provide Insights into Butenolide Core Biosynthesis
by Joachim J. Hug, Louise Kjaerulff, Ronald Garcia and Rolf Müller
Mar. Drugs 2022, 20(1), 72; https://doi.org/10.3390/md20010072 - 14 Jan 2022
Cited by 8 | Viewed by 2985
Abstract
Marine myxobacteria present a virtually unexploited reservoir for the discovery of natural products with diverse biological functions and novel chemical scaffolds. We report here the isolation and structure elucidation of eight new deoxyenhygrolides (18) from the marine myxobacterium Plesiocystis [...] Read more.
Marine myxobacteria present a virtually unexploited reservoir for the discovery of natural products with diverse biological functions and novel chemical scaffolds. We report here the isolation and structure elucidation of eight new deoxyenhygrolides (18) from the marine myxobacterium Plesiocystis pacifica DSM 14875T. The herein described deoxyenhygrolides C–J (18) feature a butenolide core with an ethyl residue at C-3 of the γ-lactone in contrast to the previously described derivatives, deoxyenhygrolides A and B, which feature an isobutyl residue at this position. The butenolide core is 2,4-substituted with a benzyl (1, 2 and 7), benzoyl (3 and 4) or benzyl alcohol (5, 6 and 8) moiety in the 2-position and a benzylidene (16) or benzylic hemiketal (7 and 8) in the 4-position. The description of these new deoxyenhygrolide derivatives, alongside genomic in silico investigation regarding putative biosynthetic genes, provides some new puzzle pieces on how this natural product class might be formed by marine myxobacteria. Full article
(This article belongs to the Special Issue Future Directions of Marine Bacterial Natural Products)
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11 pages, 5609 KiB  
Article
An Unusual Diterpene—Enhygromic Acid and Deoxyenhygrolides from a Marine Myxobacterium, Enhygromyxa sp.
by Tomohiko Tomura, Shiori Nagashima, Satoshi Yamazaki, Takashi Iizuka, Ryosuke Fudou and Makoto Ojika
Mar. Drugs 2017, 15(4), 109; https://doi.org/10.3390/md15040109 - 6 Apr 2017
Cited by 18 | Viewed by 5502
Abstract
Three new compounds, enhygromic acid (1) and deoxyenhygrolides A (2) and B (3), were isolated from a marine myxobacterium, Enhygromyxa sp. Compound 1 was found to be an acrylic acid derivative with a rare polycyclic carbon skeleton, [...] Read more.
Three new compounds, enhygromic acid (1) and deoxyenhygrolides A (2) and B (3), were isolated from a marine myxobacterium, Enhygromyxa sp. Compound 1 was found to be an acrylic acid derivative with a rare polycyclic carbon skeleton, decahydroacenaphthylene, by spectroscopic analyses. Compounds 2 and 3 were deoxy analogs of the known γ-alkylidenebutenolides, enhygrolides. Compound 1 exhibited cytotoxicity against B16 melanoma cells and anti-bacterial activity against Bacillus subtilis, and enhanced the NGF-induced neurite outgrowth of PC12 cells. Full article
(This article belongs to the Special Issue Marine Bioactive Natural Product Studies in Asia)
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