Search Results (8)

Background/Objectives: Omega-3 long-chain polyunsaturated fatty acids (PUFAs) support brain cell membrane integrity and help mitigate synaptic plasticity deficits. The endocannabinoid system (ECS) is integral to synaptic plasticity and regulates various brain functions. While PUFAs influence the ECS, the effects of omega-3 on the ECS, cognition, and behavior in a healthy brain remain unclear. Methods and Results: Here, we demonstrate that hippocampal synaptosomes from male mice fed an omega-3-rich diet exhibit increased levels of cannabinoid CB1 receptors (~30%), phospholipase C β1 (PLCβ1, ~30%), monoacylglycerol lipase (MAGL, ~30%), and cannabinoid receptor-interacting protein 1a (Crip1a, ~60%). Conversely, these synaptosomes show decreased levels of diacylglycerol lipase α (DAGLα, ~40%), synaptosomal-associated protein 25kDa (SNAP-25, ~30%), and postsynaptic density protein 95 (PSD-95, ~40%). Omega-3 intake also reduces Gαo and Gαi3 levels, though receptor-stimulated [³⁵S]GTPγS binding remains unaffected. Stimulation of the medial perforant path (MPP) induced long-term potentiation (LTP) in omega-3-fed mice. This LTP was dependent on group I metabotropic glutamate receptors (mGluR), 2 arachidonoylglycerol (2-AG), CB1 receptors, N-type Ca²⁺ channels, and actin filaments. Behaviorally, omega-3-fed mice displayed reduced exploratory behavior and significantly improved object discrimination in the novel object recognition test (NORT). They also spent more time in open arms and exhibited reduced freezing time in the elevated plus maze (EPM), indicative of reduced anxiety-like behavior. Conclusions: Our findings suggest that omega-3 leverages the ECS to enhance brain function under normal conditions. Full article

Disabled people are uniquely positioned in relation to the digital turn. Academic ableism, the inaccessibility of digital space, and gaps in digital literacy present barriers, while, at the same time, disabled, Deaf, and neurodivergent people’s access knowledge is at the forefront of innovations in culture and crip technoscience. This article explores disability, technology, and access through the concept of crip digital intimacy, a term that describes the relational and affective advances that disabled people make within digital space and through digital technology toward accessing the arts. We consider how moments of crip digital intimacy emerged through Accessing the Arts: Centring Disability Perspectives in Access Initiatives—a research project that explored how to make the arts more accessible through engaging disabled artist-participants in virtual storytelling, knowledge sharing, and art-making activities. Our analysis tracks how crip digital intimacies emerged through the ways participants collectively organized and facilitated access for themselves and each other. Guided by affordance theory and in line with the political thrust of crip technoscience, crip legibility, and access intimacy, we argue that crip digital intimacy emphasizes the interdependent and relational nature of access, recognizes the creativity and vitality of nonnormative bodyminds, and understands disability as a political—and frequently transgressive—way of being in the world. Full article

This article explores how Disabled people’s fashion hacking practices re-make worlds by expanding fashion design processes, fostering relationships, and welcoming-in desire for Disability. We share research from the second phase of our project, Cripping Masculinity, where we developed fashion hacking workshops with D/disabled, D/deaf and Mad men and masculine non-binary people. In these workshops, participants worked in collaboration with fashion researchers and students to alter, embellish, and recreate their existing garments to support their physical, emotional, and spiritual needs. We explore how our workshops heeded the principles of Disability Justice by centring flexibility of time, collective access, interdependence, and desire for intersectional Disabled embodiments. By exploring the relationships formed and clothing made in these workshops, we articulate a framework for crip fashion hacking that reclaims design from the values of the market-driven fashion industry and towards the principles of Disability Justice. This article is written as a dialogue between members of the research team, the conversational style highlights our relationship-making process and praxis. We invite educators, designers, and/or researchers to draw upon crip fashion hacking to re-make worlds by desiring with and for communities who are marginalized by dominant systems. Full article

Responding to ableist and regimented notions of time, disabled activists and disability studies scholars alike have embraced “crip time” as a modality that better accounts for the ways disability transforms chronology. By applying this critical disability framework to depictions of time in Victorian literature, my paper reveals the generative potential of nonnormative understandings of time in two foundational and widely studied texts: Charlotte Brontë’s Jane Eyre and Wilkie Collins’s The Woman in White. In each text, the presence of disability allows for the resistance to and subversion of hegemonic (and genre-based) modes of temporality. Full article

This article brings together critical disability scholarship and personal narrative, sharing the author’s pandemic story of disruption, caregiving, grief, burnout, cancer, and post-operative fatigue. It offers critical reflection on the limits of the neoliberal academy and possibilities for practicing liberatory politics within it, posing two central questions: What does it mean to crip time and centre care as an arts-based researcher? What might a commitment to honouring crip time based on radical care do for the author and their scholarship, and for others aspiring to conduct reworlding research? This analysis suggests that while committing to “slow scholarship” is a form of resistance to ableist capitalist and colonial pressures within the academy, slowness alone does not sufficiently crip research processes. Crip time, by contrast, involves multiply enfolded temporalities imposed upon (and reclaimed by) many researchers, particularly those living with disabilities and/or chronic illness. The article concludes that researchers can commit to recognizing crip time, valuing it, and caring for those living through it, including themselves, not only/necessarily by slowing down. Indeed, they can also carry out this work by actively imagining the crip futures they are striving to make along any/all trajectories and temporalities. This means simultaneously transforming academic institutions, refusing internalized pressures, reclaiming interdependence, and valuing all care work in whatever time it takes. Full article

Cannabinoid receptor-interacting protein 1a (CRIP1a) binds to the C-terminal domain of cannabinoid 1 receptor (CB1R) and regulates CB1R activities. In this study, we made Tat-CRIP1a fusion proteins to enhance CRIP1a penetration into neurons and brain and to evaluate the function of CRIP1a in neuroprotection following oxidative stress in HT22 hippocampal cells and transient forebrain ischemia in gerbils. Purified exogenous Tat-CRIP1a was penetrated into HT22 cells in a time and concentration-dependent manner and prevented H₂O₂-induced reactive oxygen species formation, DNA fragmentation, and cell damage. Tat-CRIP1a fusion protein also ameliorated the reduction of 14-3-3η expression by H₂O₂ treatment in HT22 cells. Ischemia–reperfusion damage caused motor hyperactivity in the open field test of gerbils; however, the treatment of Tat-CRIP1a significantly reduced hyperactivity 1 day after ischemia. Four days after ischemia, the administration of Tat-CRIP1a restored the loss of pyramidal neurons and decreased reactive astrocytosis and microgliosis induced by ischemic damage in the hippocampal cornu Ammonis (CA)1 region. Ischemic damage decreased 14-3-3η expression in all hippocampal sub-regions 4 days after ischemia; however, the treatment of Tat-CRIP1 ameliorated the reduction of 14-3-3η expression. These results suggest that Tat-CRIP1a attenuates neuronal damage and hyperactivity induced by ischemic damage, and it restores normal expression levels of 14-3-3η protein in the hippocampus. Full article

Undoubtedly, it is important to have an empirically effective credit risk rating method for decision-making in the financial industry, business, and even government. In our approach, for each corporate bond (CB) and its issuer, we first propose a credit risk rating (Crisk-rating) system with rating intervals for the standardized credit risk price spread (S-CRiPS) measure presented by Kariya et al. (2015), where credit information is based on the CRiPS measure, which is the difference between the CB price and its government bond (GB)-equivalent CB price. Second, for each Crisk-homogeneous class obtained through the Crisk-rating system, a term structure of default probability (TSDP) is derived via the CB-pricing model proposed in Kariya (2013), which transforms the Crisk level of each class into a default probability, showing the default likelihood over a future time horizon, in which 1545 Japanese CB prices, as of August 2010, are analyzed. To carry it out, the cross-sectional model of pricing government bonds with high empirical performance is required to get high-precision CRiPS and S-CRiPS measures. The effectiveness of our GB model and the S-CRiPS measure have been demonstrated with Japanese and United States GB prices in our papers and with an evaluation of the credit risk of the GBs of five countries in the EU and CBs issued by US energy firms in Kariya et al. (2016a, b). Our Crisk-rating system with rating intervals is tested with the distribution of the ratings of the 1545 CBs, a specific agency’s credit rating, and the ratings of groups obtained via a three-stage cluster analysis. Full article

‘Youth’ is more complicated than an age-bound period of life; although implicitly paired with developmentalism, youth is surrounded by contradictory discourses. In other work [1], I have asserted that young people are demonized as risky and rebellious, whilst simultaneously criticized for being lazy and apathetic; two intertwining, yet conflicting discourses meaning that young people’s here-and-now experiences take a backseat to a focus on reaching idealized, neoliberal adulthood [2]. Critical examination of adulthood ideals, however, shows us that ‘youthfulness’ is itself presented as a goal of adulthood [3–5], as there is a desire, as adults, to remain forever young [6]. As Blatterer puts it, the ideal is to be “adult and youthful but not adolescent” ([3], p. 74). This paper attempts to untangle some of the youth/adult confusion by asking how the aspiration/expectation of a youthful body plays out in the embodied lives of young dis/abled people. To do this, I use a feminist-disability lens to consider youth in an abstracted form, not as a life-stage, but as the end goal of an aesthetic project of the self that we are all (to differing degrees) encouraged to set out upon. Full article