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Keywords = conflicting zeitgebers

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15 pages, 1923 KiB  
Review
Circadian Misalignment and Metabolic Disorders: A Story of Twisted Clocks
by Aurore Woller and Didier Gonze
Biology 2021, 10(3), 207; https://doi.org/10.3390/biology10030207 - 10 Mar 2021
Cited by 18 | Viewed by 4528
Abstract
Biological clocks are cell-autonomous oscillators that can be entrained by periodic environmental cues. This allows organisms to anticipate predictable daily environmental changes and, thereby, to partition physiological processes into appropriate phases with respect to these changing external conditions. Nowadays our 24/7 society challenges [...] Read more.
Biological clocks are cell-autonomous oscillators that can be entrained by periodic environmental cues. This allows organisms to anticipate predictable daily environmental changes and, thereby, to partition physiological processes into appropriate phases with respect to these changing external conditions. Nowadays our 24/7 society challenges this delicate equilibrium. Indeed, many studies suggest that perturbations such as chronic jet lag, ill-timed eating patterns, or shift work increase the susceptibility to cardiometabolic disorders, diabetes, and cancers. However the underlying mechanisms are still poorly understood. A deeper understanding of this complex, dynamic system requires a global holistic approach for which mathematical modeling can be highly beneficial. In this review, we summarize several experimental works pertaining to the effect of adverse conditions on clock gene expression and on physiology, and we show how computational models can bring interesting insights into the links between circadian misalignment and metabolic diseases. Full article
(This article belongs to the Special Issue Circadian Disruption and Metabolic Disorders)
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