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Keywords = clopidogrel bisulphate

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10 pages, 1385 KiB  
Brief Report
Integral UV Spectrophotometric Methods for Determination of Clopidogrel Bisulphate and Metamizole Sodium in Rinse Waters from Industrial Equipment
by Pavel Anatolyevich Nikolaychuk
Spectrosc. J. 2025, 3(1), 2; https://doi.org/10.3390/spectroscj3010002 - 16 Jan 2025
Viewed by 1060
Abstract
In this paper, methods for the determination of clopidogrel bisulphate and metamizole sodium in rinse waters from industrial equipment, using multiwavelength UV spectrometry and the calculation of areas under curves, are proposed. Spectra were recorded in an aqueous medium without preliminary pH adjustment. [...] Read more.
In this paper, methods for the determination of clopidogrel bisulphate and metamizole sodium in rinse waters from industrial equipment, using multiwavelength UV spectrometry and the calculation of areas under curves, are proposed. Spectra were recorded in an aqueous medium without preliminary pH adjustment. A numerical integration of the spectra was performed in the wavelength range of 210 to 290 nm for clopidogrel bisulphate, and 220 to 320 nm for metamizole sodium. The methods enable the determination of clopidogrel bisulphate and metamizole sodium in solution in the concentration range of 1–100 mg/L, do not require lengthy sample preparation and complex analytical equipment, and are suitable for the routine determination of these drugs in rinse waters from industrial equipment. Full article
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15 pages, 301 KiB  
Article
New Chemometrics Mode Based on Adjacent Data Points’ Differences for the Simultaneous Determination of Clopidogrel, Atorvastatin, and Aspirin in their Combined Ternary Drug Formulation
by R’afat Mahmoud NEJEM, Mahmoud Mohamed ISSA, Alaa Abu SHANAB, Raluca-Ioana STEFAN-VAN STADEN and Hassan Y. ABOUL-ENEIN
Sci. Pharm. 2014, 82(3), 601-616; https://doi.org/10.3797/scipharm.1401-21 - 24 Mar 2014
Cited by 2 | Viewed by 1542
Abstract
A new method is proposed for the analysis of a ternary mixture composed of clopidogrel, atorvastatin, and aspirin without prior separation steps. The method combines the advantages of the mean centering of ratio spectra and derivative spectrophotometric methods. It is based on using [...] Read more.
A new method is proposed for the analysis of a ternary mixture composed of clopidogrel, atorvastatin, and aspirin without prior separation steps. The method combines the advantages of the mean centering of ratio spectra and derivative spectrophotometric methods. It is based on using the difference between adjacent data points in the absorbance spectra. The principal advantage of this method is the use of absorbance data, and not derivative data; hence the signal-to-noise ratio is not diminished. The mathematical explanation of the procedure is illustrated. Beer’s law was valid in the concentration range 0.3–35 μg.mL−1 for CLOP, 0.5–30 μg.mL−1 for ATOR, and 1–40 μg.mL−1 for ASP. Mean recoveries were obtained as 100.2, 100.1, and 100.2% for CLOP, ATOR, and ASP, respectively, in the prepared synthetic mixtures. The method has been successfully applied to the simultaneous determination of ternary mixtures of aspirin, clopidogrel bisulphate, and atorvastatin calcium. The analytical characteristics of the method were calculated. The results showed that the new method is simple, rapid, accurate, and precise. Full article
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