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Keywords = chloroanthrabenzoxocinones

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9 pages, 1404 KB  
Article
Zunyimycins B and C, New Chloroanthrabenzoxocinones Antibiotics against Methicillin-Resistant Staphylococcus aureus and Enterococci from Streptomyces sp. FJS31-2
by Yuhong Lü, Meiyun Shao, Yinyin Wang, Shengyan Qian, Miao Wang, Yingquan Wang, Xiaoqian Li, Yuxin Bao, Chengmin Deng, Changwu Yue, Daishun Liu, Ning Liu, Minghao Liu, Ying Huang, Zehui Chen and Yonglin Hu
Molecules 2017, 22(2), 251; https://doi.org/10.3390/molecules22020251 - 8 Feb 2017
Cited by 27 | Viewed by 6027
Abstract
This study performed an optimization of the fermentation conditions to activate the expression of the zunyimycin family biosynthesis genes of the zunyimycin-producing streptomycetes strain Streptomyces sp. FJS31-2. Bioassay-guided isolation and purification by varied chromatographic methods yielded two new compounds of the zunyimycin derivatives, [...] Read more.
This study performed an optimization of the fermentation conditions to activate the expression of the zunyimycin family biosynthesis genes of the zunyimycin-producing streptomycetes strain Streptomyces sp. FJS31-2. Bioassay-guided isolation and purification by varied chromatographic methods yielded two new compounds of the zunyimycin derivatives, namely, 31-2-7 and 31-2-8, accompanied with three known anthrabenzoxocinones family members of zunyimycin A, BE24566B, and chloroanthrabenzoxocinone. Their structures were elucidated by NMR, HRESIMS, IR, UV, and CD. Results showed that these two compounds were structurally similar to the previously reported compound zunyimycin A but differed in positions and number of chlorine atom substitution. The two novel compounds were called zunyimycins B and C. Antibacterial activity assay indicated that zunyimycin C showed a good inhibitory effect on the methicillin-resistant Staphylococcus aureus and Enterococci. Full article
(This article belongs to the Section Medicinal Chemistry)
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