Search Results (11)

One of the least understood and most elaborate and neglected knee stabilizers is the posterolateral corner (PLC) complex. PLC injury is associated with a high risk of re-injury, early athletic career termination, instability, progressive osteoarthritis, and a high risk of artificial knee replacement. The growing focus on the PLC, along with various recent anatomical and biomechanical studies, has provided further insights into the anatomy and function of posterolateral structures in knee stabilization and kinematics. The PLC should be considered as a functional unit, not only an anatomical unit. A low suspicion threshold should be maintained when considering PLC injuries, and thorough history evaluation, clinical examination, and adequate imaging should be conducted to reduce the chances of neglected PLC injuries. Various PLC repair and reconstruction techniques, ranging from non-anatomical to anatomical, have been introduced, with treatments increasingly favoring minimal incisions and arthroscopic procedures. Recent studies on the PCL have reported an increasing number of satisfactory clinical outcomes. This study aimed to provide a deeper understanding, as well as review the current and most feasible treatments for PLC injuries. Full article

This archival study explores the life and work of Dr. Carrie Weaver Smith (1885–1942), a Progressive Era social worker and prison warden. Specifically, I explore the first phase of her career as a House Physician at the Virginia K. Johnson Home in Dallas, Texas (1911–1915) and as the first Superintendent of the Texas State Training School for Girls in Gainesville, Texas (1916–1925). Using archival research, I detail three conflicts that defined Dr. Smith’s superintendency: her fight to reclassify a youth prison as a school, her challenges to a Ku Klux Klan-dominated legislature, and her refusal to cede authority to a State Board of Control. Together, these conflicts led the Board to terminate Dr. Smith’s position, an outcome that would replay twice more before she retired from prisonwork. I argue that when most reformers made significant concessions, compromising their visions to maintain state funding and political allyship, Dr. Smith stood out for her record of refusal. And yet, like other reformers, she left Texas with the capacity to imprison more women and girls than ever before. Full article

Soccer is a sport with a high incidence of injuries. The most common injury occurs when the anterior cruciate ligament of the knee has undergone a sprain, strain, or partial or total rupture. Besides fitness factors (e.g., proprioception, balance and strength capabilities), a principal cause of ACL injuries is sport shoes and playing surfaces. Especially with the emergence of artificial surfaces (rubbers, turfs, concrete, asphalt, red turf), the ACL injuries dramatically increase. The cost of ACL injuries is high both in terms of career termination and in social and economic costs. Thus, it is necessary to understand the impact of sport shoes and playing surfaces on the ACL and how it can be mitigated. The present literature review followed the PRISMA methodology to identify the major biomechanical factors influencing the behavior of surfaces and shoes in relation to the ACL damage. Fifty-eight papers were identified. After reviewing the mechanism of injuries, we identified several distinct factors: type of outsole and mechanical arrangement of the outsoles; shear forces; characteristics of artificial turf surfaces; effect of weather on artificial surface aging and change in mechanical characteristics; outsole/ground interface; and the frictional, tractional and rotational forces in the pathogenesis of ACL injuries in soccer. Full article

Osteoarthritis (OA) is a widespread osteoarticular pathology characterized by progressive hyaline cartilage degradation, exposing horses to impaired well-being, premature career termination, alongside substantial financial losses for horse owners. Among the new therapeutic strategies for OA, using mesenchymal stromal cell (MSC)-derived exosomes (MSC-exos) appears to be a promising option for conveying MSC therapeutic potential, yet avoiding the limitations inherent to cell therapy. Here, we first purified and characterized exosomes from MSCs by membrane affinity capture (MAC) and size-exclusion chromatography (SEC). We showed that intact MSC-exos are indeed internalized by equine articular chondrocytes (eACs), and then evaluated their functionality on cartilaginous organoids. Compared to SEC, mRNA and protein expression profiles revealed that MAC-exos induced a greater improvement of eAC-neosynthesized hyaline-like matrix by modulating collagen levels, increasing PCNA, and decreasing Htra1 synthesis. However, because the MAC elution buffer induced unexpected effects on eACs, an ultrafiltration step was included to the isolation protocol. Finally, exosomes from MSCs primed with equine pro-inflammatory cytokines (IL-1β, TNF-α, or IFN-γ) further improved the eAC hyaline-like phenotype, particularly IL-1β and TNF-α. Altogether, these findings indicate the importance of the exosome purification method and further demonstrate the potential of pro-inflammatory priming in the enhancement of the therapeutic value of MSC-exos for equine OA treatment. Full article

Current social trends of delayed reproduction to the fourth and fifth decade of life call for a better understanding of reproductive aging. Demographic studies correlated late reproduction with general health and longevity. Telomeres, the protective ends of eukaryotic chromosomes, were implicated in various aging-associated pathologies and longevity. To examine whether telomeres are also associated with reproductive aging, we measured by Southern analysis the terminal restriction fragments (TRF) in leukocytes of women delivering a healthy infant following a spontaneous pregnancy at 43–48 years of age. We compared them to age-matched previously fertile women who failed to conceive above age 41. The average TRF length in the extended fertility group (9350 bp) was significantly longer than in the normal fertility group (8850 bp; p-value = 0.03). Strikingly, excluding women with nine or more children increased the difference between the groups to over 1000 bp (9920 and 8880 bp; p-value = 0.0009). Nevertheless, we observed no apparent effects of pregnancy, delivery, or parity on telomere length. We propose that longer leukocyte telomere length reflects higher oocyte quality, which can compensate for other limiting physiological and behavioral factors and enable successful reproduction. Leukocyte telomere length should be further explored as a novel biomarker of oocyte quality for assessing reproductive potential and integrating family planning with demanding women’s careers. Full article

This paper investigates high-performance athletes’ development of their financial literacy and self-management skills and the related organisational support available to them during their athletic careers. The data were collected from 20 retired high-performance athletes (10 male and 10 female) representing six different countries (Japan, Mexico, Portugal, Singapore, South Korea, and the UK). Thematic analysis was applied to the processing of the data and five themes emerged: (1) Funding battles: financial challenges and misjudgements; (2) Coping Strategies; (3) Support from sponsors, parents, and sport organisations; (4) Development of Financial Literacy; and (5) Life After Sport. The data indicates that athletes experienced financial challenges due to a lack of organisational support, reduced or terminated funding, and limited opportunities to access sponsorship. Typically, athletes developed their financial literacy and self-management skills by ‘self-help’ or ‘trial and error’. The findings contribute to both literature and practice by providing empirical evidence on the coping strategies adopted by athletes in order to overcome financial challenges and on the methods used in order to develop their financial literacy and self-management skills. These findings inform sport organisations and governing bodies to develop support schemes for high-performance athletes as well as deepen our knowledge of athletes’ career development and transitions focusing on the financial aspect. Full article

An athletic career is a succession of stages and transitions (normative and non-normative), which may have decisive effects on either maintaining a satisfactory and/or successful course or deciding about premature career termination. The main purpose of this study was to identify differences between swimmers (M_age = 21.32, SD = 2.62) who after undergoing the transition from junior to senior level either: (a) continued their career hoping to improve their performance regardless of low success at the elite level—Group I; or (b) decided on premature athletic career termination—Group II. The criteria for inclusion included having undergone the transition from junior to senior level and having competed at elite level for at least a year (M = 4.14 years, SD = 1.74). The participants were administered a demographic survey and a structured interview. The results revealed differences in developmental stages. The exploration phase was longer (M_{Group I} = 5.8 yrs, SD = 2.04, M_{Group II} = 4.6 yrs, SD = 2.4; Z = −1.902, p = 0.057); the commitment phase was shorter (M_{Group I} = 3.6 yrs, SD = 1.3; M_{Group II} = 4.6 yrs, SD = 1.7; Z = −1.735, p = 0.083); the number of hours of structured practice were (M_{Group I} = 5975, SD = 2474; M_{Group II} = 7623, SD = 2660, Z = −1.928, p = 0.054); the number of perceived costs were (Group I = 22, Group II = 34; Z = −2.209, p = 0.0027); and the most often pointed benefits of a sporting career were (Group I—94% health & physical fitness; Group II—88% personal growth & life skills). Furthermore, essential inhibitors and facilitators of athletes’ development were identified. The findings of the study have practical applications for athletes, coaches, parents and sport psychology professionals. For instance, appropriate social support can help to prevent elite athletes’ premature career termination from professional sport during and after their normative transition from junior to senior level. Full article

The purpose of the article is to study the socio-political attitudes of Moscow students, which determine their life strategies in the public sphere. An empirical basis for the study was the sociological survey of students of three universities in Moscow (n = 768). The questionnaire was partially based on Milton Rokeach’s terminal personal values indicators and the methodology of studying political culture of Gabriel Almond and Sidney Verba, adapted to a Russian context. The survey data operationalization let us represent a structural model of socio-political attitudes of Moscow students, which consists of indicators of four levels: value, emotional, cognitive, and strategic. The results showed that students in Moscow share the values and patriotic feelings of the elder generations. The influence of gender and age factors was most pronounced on the level of personal values. Despite of the field of their study, students in Moscow can be described as quite energetic and optimistic young citizens, equally family and career oriented with not a high interest in politics and weak political activity. Authors discussed their main findings with the results of previously obtained all-Russian and regional youth studies. Full article

With the growth of animal-assisted interventions, the number of animals designated to work as therapy animals continues to increase. These animals participate in this work in varying capacities during life, but there will be a point in time when the animal can no longer engage in these activities. The concept of retirement, or withdrawing the animal from its working life, is an important phase of life that every therapy animal will inevitably face. Retirement is typically regarded as a well-deserved reward earned after a lifetime of work, but this termination of an animal’s career has potential positive and negative implications for animal, handler, and human participants in these interventions. The question of precisely when and how to appropriately retire an animal is usually answered at the discretion of the handler; however, the validity of this question remains largely unanswered without scientific evidence. The purpose of this review is to describe the implications of therapy animal retirement for the handler, participant, and animal and to discuss the challenges in determining when to retire a therapy animal. Full article

The aim of this study was to explore the process of career termination of elite soccer players, comparing the quality and the resources to support career termination over the last three decades. To this end, was developed a questionnaire defined by four sections: (a) biographical data, (b) athletic career, (c) quality of career termination and (d) available resources at the moment of career termination. Ninety male former elite Portuguese soccer players participated in this study. The results highlighted a decrease in the length of athletic career as football players and an increase in the number of years as youth players over the last 30 years. The results also revealed that the quality of career termination was difficult. The analysis of resources for career termination revealed an increase in a high level of education over the years. Despite the evolution in the level athletes’ education in the last three decades, the athletic career termination remained difficult and it was reported that they did not plan their career termination. In line with previous studies, the results highlight that the lack of plans for career termination is one of the most important factors that constrain the quality of career transition. Full article

Trigeminal-nerve-mediated headshaking represents a major welfare challenge for owners and veterinarians and is caused by a low threshold firing of the trigeminal nerve resulting in pain manifested as violent head jerking that often terminates the horse’s career and life due to poor quality of life and suffering. As metabolic changes such as acid–base status and electrolytes play a role in nerve firing, this study sought to assess the effects following administration of hypertonic solutions on headshaking behavior in affected horses. This prospective randomized controlled crossover design utilized six horses affected with trigeminal-mediated headshaking and three treatment groups receiving intravenous administration of 5% dextrose solution at 2 mL/kg bwt (DS), NaCl 7.5% at 4 mL/kg bwt (HS), or NaHCO₃ 8.4% at 2 mmol/kg bwt (HB). Horses were assessed for headshaking behavior changes at times T0 (baseline, before infusion) and T15, 30, 60, 120 min post infusion. Venous blood variables: pH, HCO₃⁻, standard base excess (SBE), Na⁺, Cl⁻, K⁺, Ca²⁺, Mg²⁺, total magnesium (tMg), glucose, and lactate were measured at T0 (baseline, before infusion) and T5, 15, 30, 60, 120 min post infusion. Strong ion difference (SID) and anion gap (AG) were calculated for each time point. With HB treatment, there was greater than 50% reduction in headshaking rate. There was an effect of time on increasing headshaking rate. There was an effect of breed on headshaking rate. Changes in blood parameters following DS were virtually absent. Infusion of HS caused mild changes and did not vary much from baseline except for SID and AG. Only infusion of HB caused blood pH and HCO₃⁻ to be outside of the physiologic range (alkalemia and metabolic alkalosis, respectively), SBE to double or triple, AG to decrease, and SID to increase compared to baseline. Infusion of DS was followed by increase in blood glucose and decrease in blood Na⁺. Infusion of HS was followed by increase in Na⁺ and Cl⁻ and decrease in Mg²⁺. Infusion of HB was followed by decrease in Mg²⁺. Blood tMg, K⁺, and Ca²⁺ decreased slightly, but did not vary greatly from baseline following any of the treatments, remaining within physiologic ranges. Changes in blood composition were transient. Among all treatments, only HB had an effect on headshaking rate. The limited effects following these fluids were likely due to normal mechanisms of regulation of blood levels of pH and electrolytes. Further investigations of changes in electrolytes that might affect nerve firing should be explored. Full article