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Keywords = benzil and isoflavone derivatives

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8 pages, 671 KB  
Article
New Benzil and Isoflavone Derivatives with Cytotoxic and NO Production Inhibitory Activities from Placolobium vietnamense
by Lien T. M. Do, Tuyet T. N. Huynh and Jirapast Sichaem
Molecules 2022, 27(14), 4624; https://doi.org/10.3390/molecules27144624 - 20 Jul 2022
Cited by 2 | Viewed by 2278
Abstract
The phytochemical investigation of Placolobium vietnamense stems led to the isolation of a new isoflavone derivative (1) and three new benzil derivatives (24), together with four known pyranoisoflavones (58). The structures of all [...] Read more.
The phytochemical investigation of Placolobium vietnamense stems led to the isolation of a new isoflavone derivative (1) and three new benzil derivatives (24), together with four known pyranoisoflavones (58). The structures of all isolated compounds were determined on the basis of extensive spectroscopic analyses, including NMR and HRMS spectral data, as well as comparison of their spectroscopic data with those reported in the literature. The cytotoxicity of all isolated compounds was assessed against the human liver hepatocellular carcinoma (Hep G2) cell line, and compound 1 displayed the most significant cytotoxicity with an IC50 value of 8.0 μM. Furthermore, all isolated compounds were also tested for their inhibitory activity against NO production in RAW 264.7 macrophages. Of these, compound 1 exhibited the strongest inhibitory efficacy against the LPS-induced NO production with the IC50 value of 13.7 μM. Full article
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