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Keywords = aptamer-small molecule conjugated systems

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39 pages, 2176 KiB  
Review
Progress and Challenges in Developing Aptamer-Functionalized Targeted Drug Delivery Systems
by Feng Jiang, Biao Liu, Jun Lu, Fangfei Li, Defang Li, Chao Liang, Lei Dang, Jin Liu, Bing He, Shaikh Atik Badshah, Cheng Lu, Xiaojuan He, Baosheng Guo, Xiao-Bing Zhang, Weihong Tan, Aiping Lu and Ge Zhang
Int. J. Mol. Sci. 2015, 16(10), 23784-23822; https://doi.org/10.3390/ijms161023784 - 9 Oct 2015
Cited by 85 | Viewed by 12769
Abstract
Aptamers, which can be screened via systematic evolution of ligands by exponential enrichment (SELEX), are superior ligands for molecular recognition due to their high selectivity and affinity. The interest in the use of aptamers as ligands for targeted drug delivery has been increasing [...] Read more.
Aptamers, which can be screened via systematic evolution of ligands by exponential enrichment (SELEX), are superior ligands for molecular recognition due to their high selectivity and affinity. The interest in the use of aptamers as ligands for targeted drug delivery has been increasing due to their unique advantages. Based on their different compositions and preparation methods, aptamer-functionalized targeted drug delivery systems can be divided into two main categories: aptamer-small molecule conjugated systems and aptamer-nanomaterial conjugated systems. In this review, we not only summarize recent progress in aptamer selection and the application of aptamers in these targeted drug delivery systems but also discuss the advantages, challenges and new perspectives associated with these delivery systems. Full article
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