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Keywords = andrastin-type meroterpenoids

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9 pages, 865 KB  
Article
Two New Andrastin-Type Meroterpenoids from Marine Sponge-Derived Fungus Botryosporium sp. S5I2-1
by Hui-Xian Liang, Wan-Ying Guo, Shi-Hai Xu and Bing-Xin Zhao
Molecules 2026, 31(2), 294; https://doi.org/10.3390/molecules31020294 - 14 Jan 2026
Abstract
Botryomeroterpenoids A (1) and B (2), two new andrastin-type meroterpenoids, along with two known analogues (3 and 4), were isolated from sponge-derived fungus Botryosporium sp. S5I2-1. Their structures were characterized by detailed spectroscopic analysis. Meanwhile, the absolute [...] Read more.
Botryomeroterpenoids A (1) and B (2), two new andrastin-type meroterpenoids, along with two known analogues (3 and 4), were isolated from sponge-derived fungus Botryosporium sp. S5I2-1. Their structures were characterized by detailed spectroscopic analysis. Meanwhile, the absolute configurations of 1 and 2 were elucidated by comparing experimental and calculated ECD spectra. Compounds 1 and 2 were the first examples of andrastin-type meroterpenoids isolated from this genus, especially Compound 1 which represented the initial instance of 18-norandrastin-type meroterpenoids. Furthermore, the antibacterial activities of all compounds were also evaluated. However, the results indicated that these compounds showed no significant inhibitory activity against the tested bacteria with minimum inhibitory concentration (MIC) values of 32–64 μg/mL. Full article
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10 pages, 1524 KB  
Article
Hemiacetalmeroterpenoids A–C and Astellolide Q with Antimicrobial Activity from the Marine-Derived Fungus Penicillium sp. N-5
by Tao Chen, Wencong Yang, Taobo Li, Yihao Yin, Yufeng Liu, Bo Wang and Zhigang She
Mar. Drugs 2022, 20(8), 514; https://doi.org/10.3390/md20080514 - 13 Aug 2022
Cited by 16 | Viewed by 3015
Abstract
Four new compounds including three andrastin-type meroterpenoids hemiacetalmeroterpenoids A-C (13), and a drimane sesquiterpenoid astellolide Q (15), together with eleven known compounds (414) were isolated from the cultures of the marine-derived fungus Penicillium [...] Read more.
Four new compounds including three andrastin-type meroterpenoids hemiacetalmeroterpenoids A-C (13), and a drimane sesquiterpenoid astellolide Q (15), together with eleven known compounds (414) were isolated from the cultures of the marine-derived fungus Penicillium sp. N-5, while compound 14 was first isolated from a natural source. The structures of the new compounds were determined by analysis of detailed spectroscopic data, and the absolute configurations were further decided by a comparison of the experimental and calculated ECD spectra. Hemiacetalmeroterpenoid A (1) possesses a unique and highly congested 6,6,6,6,5,5-hexa-cyclic skeleton. Moreover, the absolute configuration of compound 14 was also reported for the first time. Compounds 1, 5 and 10 exhibited significant antimicrobial activities against Penicillium italicum and Colletrichum gloeosporioides with MIC values ranging from 1.56 to 6.25 μg/mL. Full article
(This article belongs to the Special Issue Diversity of Marine Fungi as a Source of Bioactive Natural Products)
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9 pages, 1288 KB  
Article
New Andrastin-Type Meroterpenoids from the Marine-Derived Fungus Penicillium sp.
by Jinwei Ren, Ruiyun Huo, Gaoran Liu and Ling Liu
Mar. Drugs 2021, 19(4), 189; https://doi.org/10.3390/md19040189 - 27 Mar 2021
Cited by 31 | Viewed by 3794
Abstract
Three new andrastin-type meroterpenoids penimeroterpenoids A–C (13) together with two known analogs (4 and 5) were isolated from the cultures of the marine-derived Penicillium species (sp.). The structures of the new compounds were elucidated on the basis [...] Read more.
Three new andrastin-type meroterpenoids penimeroterpenoids A–C (13) together with two known analogs (4 and 5) were isolated from the cultures of the marine-derived Penicillium species (sp.). The structures of the new compounds were elucidated on the basis of 1- and 2-dimensional (1D/2D) Nuclear Magnetic Resonance (NMR) spectroscopic and mass spectrometric analysis. The absolute configurations of 13 were determined by comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Compound 1 showed moderate cytotoxicity against A549, HCT116, and SW480 cell lines. Full article
(This article belongs to the Special Issue Marine Fungal Metabolites: Structures, Activities and Biosynthesis)
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