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Keywords = amphiphilies

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13 pages, 8892 KiB  
Article
Injectable Thermo-Responsive Peptide Hydrogels and Its Enzyme Triggered Dynamic Self-Assembly
by Bowen Yin, Ruoxue Wang, Yu Guo, Liuxuan Li and Xiuli Hu
Polymers 2024, 16(9), 1221; https://doi.org/10.3390/polym16091221 - 26 Apr 2024
Cited by 3 | Viewed by 1926
Abstract
Endogenous stimuli-responsive injectable hydrogels hold significant promise for practical applications due to their spatio-temporal controllable drug delivery. Herein, we report a facile strategy to construct a series of in situ formation polypeptide hydrogels with thermal responsiveness and enzyme-triggered dynamic self-assembly. The thermo-responsive hydrogels [...] Read more.
Endogenous stimuli-responsive injectable hydrogels hold significant promise for practical applications due to their spatio-temporal controllable drug delivery. Herein, we report a facile strategy to construct a series of in situ formation polypeptide hydrogels with thermal responsiveness and enzyme-triggered dynamic self-assembly. The thermo-responsive hydrogels are from the diblock random copolymer mPEG-b-P(Glu-co-Tyr). The L-glutamic acid (Glu) segments with different γ-alkyl groups, including methyl, ethyl, and n-butyl, offer specific secondary structure, facilitating the formation of hydrogel. The L-tyrosine (Tyr) residues not only provide hydrogen-bond interactions and thus adjust the sol–gel transition temperatures, but also endow polypeptide enzyme-responsive properties. The PTyr segments could be phosphorylated, and the phosphotyrosine copolymers were amphiphilies, which could readily self-assemble into spherical aggregates and transform into sheet-like structures upon dephosphorylation by alkaline phosphatase (ALP). P(MGlu-co-Tyr/P) and P(MGlu-co-Tyr) copolymers showed good compatibility with both MC3T3-E1 and Hela cells, with cell viability above 80% at concentrations up to 1000 μg/mL. The prepared injectable polypeptide hydrogel and its enzyme-triggered self-assemblies show particular potential for biomedical applications. Full article
(This article belongs to the Special Issue Biocompatible Polymers for Tissue Engineering and Drug Delivery)
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25 pages, 3063 KiB  
Review
Formation of Self-Assembled Anticorrosion Films on Different Metals
by Judit Telegdi
Materials 2020, 13(22), 5089; https://doi.org/10.3390/ma13225089 - 11 Nov 2020
Cited by 45 | Viewed by 5041
Abstract
The review will first discuss shortly the phenomenon of corrosion and enroll some general possibilities to decrease the rate of this deterioration. The stress will be laid upon the presentation of anticorrosive self-assembled molecular (SAM) layers as well as on the preparation technology [...] Read more.
The review will first discuss shortly the phenomenon of corrosion and enroll some general possibilities to decrease the rate of this deterioration. The stress will be laid upon the presentation of anticorrosive self-assembled molecular (SAM) layers as well as on the preparation technology that is a simple technique, does not need any special device, and can be applied on different solids (metals or non-metals) alone or in combination. The paper groups the chemicals (mainly amphiphiles) that can develop nanolayers on different pure or oxidized metal surfaces. The history of the self-assembled molecular layer will be discussed from the beginning of the first application up to now. Not only the conditions of the nanofilm preparation as well as their characterization will be discussed, but the methods that can evaluate the corrosion-inhibiting efficiency of the SAM layers under a corrosive environment will be demonstrated as well. Full article
(This article belongs to the Special Issue Self-Assembled Films for Improved Corrosion Resistance)
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