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Keywords = alveolitis sicca dolorosa

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10 pages, 1401 KiB  
Article
Hyaluronic Acid-Based Medical Device for Treatment of Alveolar Osteitis—Clinical Study
by Jakub Suchánek, Romana Koberová Ivančaková, Radovan Mottl, Klára Zoe Browne, Kristýna Charlotte Pilneyová, Nela Pilbauerová, Jan Schmidt and Tereza Suchánková Kleplová
Int. J. Environ. Res. Public Health 2019, 16(19), 3698; https://doi.org/10.3390/ijerph16193698 - 1 Oct 2019
Cited by 20 | Viewed by 5068
Abstract
Alveolar Osteitis (AO) is a complication following the extraction of a tooth. AO manifests through localized pain in, and around, the extraction site, where the post-operative blood clot has been disintegrated. The aim of this single cohort study was to evaluate the outcome [...] Read more.
Alveolar Osteitis (AO) is a complication following the extraction of a tooth. AO manifests through localized pain in, and around, the extraction site, where the post-operative blood clot has been disintegrated. The aim of this single cohort study was to evaluate the outcome of a treatment of AO, using a pharmacological device composed of hyaluronic acid and octenidine dihydrochloride. The tested device is a sponge-like material, composed solely of a fully dissoluble medicaments (hyaluronic acid, calcium chloride, and octenidine dihydrochloride). It was designed to serve as a non-toxic, slow-dissolving antiseptic, that adheres to mucosa and obturates the wound. This study includes 58 subjects who were diagnosed with AO. The tested device was administered once daily until local pain subsided to < 20 mm of the Visual Analog Scale (VAS). The treatment was considered effective when the pain subsided to < 20 mm VAS in < 8 days of treatment; as per comparative studies. Our findings provide a statistically significant success rate of 96.0% (95.0% confidence interval of 75.75% to 97.8%) after pharmacological device administrations. No adverse medical effects were detected. Acquired data confirmed that lyophilized hyaluronic acid, combined with octenidine, is effective for the treatment of AO. The results are clinically important as AO is a common complication after third molar extractions. Full article
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