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Keywords = alkene hydroalkylation

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31 pages, 8823 KiB  
Review
Recent Advances in Carbon-Centered Radical-Initiated Olefin Transformation Chemistry
by Huazhan Ren, Ming Hu and Jinheng Li
Catalysts 2025, 15(5), 461; https://doi.org/10.3390/catal15050461 - 8 May 2025
Viewed by 971
Abstract
In recent years, carbon-centered radical-initiated olefin transformation reactions, including alkene Heck-type alkylation, alkene hydroalkylation, and alkene difunctionalization reactions, have attracted increasing attention and been extensively developed. This review summarizes the recent advances in carbon-centered radical-initiated olefin transformation chemistry, such as radical-mediated alkene Heck-type [...] Read more.
In recent years, carbon-centered radical-initiated olefin transformation reactions, including alkene Heck-type alkylation, alkene hydroalkylation, and alkene difunctionalization reactions, have attracted increasing attention and been extensively developed. This review summarizes the recent advances in carbon-centered radical-initiated olefin transformation chemistry, such as radical-mediated alkene Heck-type alkylation, alkene hydroalkylation, and radical-mediated alkene difunctionalization reactions. This area of research is divided into several sections based on the types of olefin transformation reactions and the divergent formation processes of the carbon-centered radicals. Drawing extensively on our group’s investigations, we show that efficient olefin transformation strategies have gained significant traction in synthetic chemistry due to their ability to rapidly install functional groups and enhance molecular complexity. Full article
(This article belongs to the Special Issue Recent Catalysts for Organic Synthesis)
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11 pages, 1534 KiB  
Article
Gold-Catalyzed Addition of β-Ketoesters to Alkenes: Influence of Electronic and Steric Effects in the Reaction Outcome
by Agustina La-Venia, Mirta P. Mischne and Ernesto G. Mata
Molecules 2018, 23(3), 629; https://doi.org/10.3390/molecules23030629 - 10 Mar 2018
Viewed by 3783
Abstract
The gold-catalyzed intermolecular hydroalkylation of olefins with β-ketoesters represents a conceptually attractive and useful synthetic tool; however, it has been scarcely applied, remaining a challenge for chemists. The aim of the current study was to investigate the addition of these 1,3-diketo-compounds to alkenes [...] Read more.
The gold-catalyzed intermolecular hydroalkylation of olefins with β-ketoesters represents a conceptually attractive and useful synthetic tool; however, it has been scarcely applied, remaining a challenge for chemists. The aim of the current study was to investigate the addition of these 1,3-diketo-compounds to alkenes under gold catalysis conditions, in order to establish the electronic and steric effects of the alkenyl substrates in the reaction outcome. The screening of different catalyst systems and diverse olefins enabled defining the alkenyl requirements and the best reaction conditions to efficiently achieve the coupled products. Full article
(This article belongs to the Special Issue Organometallic Catalysis in Organic Synthesis)
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