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Keywords = alfa-lipoic acid

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12 pages, 5375 KiB  
Article
Electrochemically Obtained Poly(3,4-ethylenedioxythiophene) Layers for Electroanalytical Determination of Lipoic Acid
by Vasilena Karabozhikova and Vessela Tsakova
Coatings 2023, 13(12), 2014; https://doi.org/10.3390/coatings13122014 - 28 Nov 2023
Cited by 2 | Viewed by 1350
Abstract
Poly(3,4-ethylenedioxythiophene) (PEDOT) is a conducting polymer with intrinsic redox activity often used to facilitate electrooxidation reactions. PEDOT coatings with different thicknesses are obtained via electrochemical polymerization in the presence of either polysterensulfonate (PSS) or dodecylsulfate (SDS) anions. The electrooxidation of alfa lipoic acid [...] Read more.
Poly(3,4-ethylenedioxythiophene) (PEDOT) is a conducting polymer with intrinsic redox activity often used to facilitate electrooxidation reactions. PEDOT coatings with different thicknesses are obtained via electrochemical polymerization in the presence of either polysterensulfonate (PSS) or dodecylsulfate (SDS) anions. The electrooxidation of alfa lipoic acid (ALA) is studied depending on the thickness of the polymer coatings and the counterions used for their synthesis. The kinetics of ALA oxidation is found to differ for thin and thick PEDOT coatings with diffusion limitations observed for thin layers. For thick coatings, the rate-determining step varies from adsorption to diffusion depending on the ALA concentration. The type of counterion affects both the ALA oxidation peak currents and the peak potential. SDS-doped PEDOT coatings show a shift in the oxidation peak to positive potentials and higher ALA oxidation currents. The effect is commented in terms of a larger electroactive surface area and possible specific hydrophobic polymer/analyte interactions. For thin PEDOT coatings, the concentration dependence of the voltammetric peaks is linear in a wide concentration range (40 to 1000 µM), whereas the use of differential pulse voltammetry results in a linear response in a lower concentration range (8–200 µM) suitable for practical applications. Full article
(This article belongs to the Special Issue Electrochemical Deposition: Properties and Applications)
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12 pages, 446 KiB  
Review
Therapeutic Potential of Alpha-Lipoic Acid in Viral Infections, including COVID-19
by Stela Dragomanova, Simona Miteva, Ferdinando Nicoletti, Katia Mangano, Paolo Fagone, Salvatore Pricoco, Hristian Staykov and Lyubka Tancheva
Antioxidants 2021, 10(8), 1294; https://doi.org/10.3390/antiox10081294 - 16 Aug 2021
Cited by 24 | Viewed by 11595
Abstract
Oxidative stress (OS), resulting from a disrupted balance between reactive oxygen species (ROS) and protective antioxidants, is thought to play an important pathogenetic role in several diseases, including viral infections. Alpha-lipoic acid (LA) is one of the most-studied and used natural compounds, as [...] Read more.
Oxidative stress (OS), resulting from a disrupted balance between reactive oxygen species (ROS) and protective antioxidants, is thought to play an important pathogenetic role in several diseases, including viral infections. Alpha-lipoic acid (LA) is one of the most-studied and used natural compounds, as it is endowed with a well-defined antioxidant and immunomodulatory profile. Owing to these properties, LA has been tested in several chronic immunoinflammatory conditions, such as diabetic neuropathy and metabolic syndrome. In addition, a pharmacological antiviral profile of LA is emerging, that has attracted attention on the possible use of this compound for the cotreatment of several viral infections. Here, we will review the emerging literature on the potential use of LA in viral infections, including COVID-19. Full article
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