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Keywords = Zn-substituted brushite cement

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17 pages, 6747 KiB  
Article
Antibacterial Composite Material Based on Polyhydroxybutyrate and Zn-Doped Brushite Cement
by Inna V. Fadeeva, Dina V. Deyneko, Alexander V. Knotko, Anatoly A. Olkhov, Pavel V. Slukin, Galina A. Davydova, Taisiia A. Trubitsyna, Ilya I. Preobrazhenskiy, Alevtina N. Gosteva, Iulian V. Antoniac and Julietta V. Rau
Polymers 2023, 15(9), 2106; https://doi.org/10.3390/polym15092106 - 28 Apr 2023
Cited by 12 | Viewed by 2797
Abstract
A composite material based on electrospinning printed polyhydroxybutyrate fibers impregnated with brushite cement containing Zn substitution was developed for bone implant applications. Powder X-ray Diffraction (PXRD), Fourier Transform Infrared Spectroscopy and Scanning Electron Microscopy were applied for materials characterization. Soaking the composite in [...] Read more.
A composite material based on electrospinning printed polyhydroxybutyrate fibers impregnated with brushite cement containing Zn substitution was developed for bone implant applications. Powder X-ray Diffraction (PXRD), Fourier Transform Infrared Spectroscopy and Scanning Electron Microscopy were applied for materials characterization. Soaking the composite in Ringer’s solution led to the transformation of brushite into apatite phase, accompanied by the morphology changes of the material. The bending strength of the composite material was measured to be 3.1 ± 0.5 MPa. NCTC mouse fibroblast cells were used to demonstrate by means of the MTT test that the developed material was not cytotoxic. The behavior of the human dental pulp stem cells on the surface of the composite material investigated by the direct contact method was similar to the control. It was found that the developed Zn containing composite material possessed antibacterial properties, as testified by microbiology investigations against bacteria strains of Escherichia coli and Staphylococcus aureus. Thus, the developed composite material is promising for the treatment of damaged tissues with bacterial infection complications. Full article
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17 pages, 560 KiB  
Review
Brushite-Forming Mg-, Zn- and Sr-Substituted Bone Cements for Clinical Applications
by Sandra Pina and José M.F. Ferreira
Materials 2010, 3(1), 519-535; https://doi.org/10.3390/ma3010519 - 18 Jan 2010
Cited by 64 | Viewed by 17019
Abstract
Calcium phosphate cements have been in clinical use for the last 10 years. Their most salient features include good biocompatibility, excellent bioactivity, self-setting characteristics, low setting temperature, adequate stiffness, and easy shaping to accomodate any complicated geometry. They are commonly used in filling [...] Read more.
Calcium phosphate cements have been in clinical use for the last 10 years. Their most salient features include good biocompatibility, excellent bioactivity, self-setting characteristics, low setting temperature, adequate stiffness, and easy shaping to accomodate any complicated geometry. They are commonly used in filling bone defects and trauma surgeries as mouldable paste-like bone substitute materials. Substitution of trace elements, such as Mg, Sr and Zn ions, into the structure of calcium phosphates is the subject of widespread investigation nowadays, because of their impending role in the biological process. Subtle differences in composition and structure of these materials may have a profound effect on their in vivo behaviour. Therefore, the main goal of this paper is to provide a simple, but comprehensive overview of the present achievements relating to brushite-forming cements doped with Mg, Zn and Sr, and to identify new developments and trends. In particular, the influence of ionic substitution on the chemical, physical and biological properties of these materials is discussed. Full article
(This article belongs to the Special Issue Ceramics for Healthcare)
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