Search Results (5)

Radiotherapy for pediatric brain tumors is associated with reduced white matter structural integrity and neurocognitive decline. Superior cognitive outcomes have been reported following proton radiotherapy (PRT) compared to photon radiotherapy (XRT), presumably due to improved sparing of normal brain tissue. This exploratory study examined the relationship between white matter change and late cognitive effects in pediatric brain tumor survivors treated with XRT versus PRT. Pediatric brain tumor survivors treated with XRT (n = 10) or PRT (n = 12) underwent neuropsychological testing and diffusion weighted imaging >7 years post-radiotherapy. A healthy comparison group (n = 23) was also recruited. Participants completed age-appropriate measures of intellectual functioning, visual-motor integration, and motor coordination. Tractography was conducted using automated fiber quantification (AFQ). Fractional anisotropy (FA), axial diffusivity (AD), and radial diffusivity (RD) were extracted from 12 tracts of interest. Overall, both white matter integrity (FA) and neuropsychological performance were lower in XRT patients while PRT patients were similar to healthy control participants with respect to both FA and cognitive functioning. These findings support improved long-term outcomes in PRT versus XRT. This exploratory study is the first to directly support for white matter integrity as a mechanism of cognitive sparing in PRT. Full article

This paper proposes a design procedure to determine the optimal configuration of multi-degrees of freedom (MDOF) multiple tuned mass dampers (MTMD) to mitigate the global dynamic aeroelastic response of aerospace structures. The computation of the aerodynamic excitations is performed considering two models of atmospheric disturbances, namely, the Power Spectral Density (PSD) modelled with the Davenport Spectrum (DS) and the Tuned Discrete Gust (TDG) with the one-minus cosine profile. In order to determine the optimum sets of MTMD, a Multi-objective design Optimization considering Genetic Algorithm (MOGA) is implemented, where the selected fitness functions for the analysis are the minimization of the total mass of the resonators as well as the concurrent minimization of the peak displacements of a specified structural node in all translational degrees of freedom. A case study is presented to demonstrate the proposed methodology, where the optimal sets of MTMD are determined for the concurrent minimization of the pointing error of a truss-like antenna structure as well as the mass of the considered MTMD. It is found that the placement of the MTMD in the primary reflector of the antenna structure provided a maximum reduction in the pointing error of 62.0% and 39.2%, considering the PSD and the TDG models, respectively. Finally, this paper presents an advanced framework to estimate optimal parameters of MTMD control devices under convoluted loading cases as an initial step towards the use of such passive systems in applications that commonly employ active or semi-active solutions. Full article

The formation of aerenchyma in adventitious roots is one of the most crucial adaptive traits for waterlogging tolerance in plants. Pasture grasses, like other crops, can be affected by waterlogging, and there is scope to improve tolerance through breeding. In this study, two summer-active cocksfoot (Dactylis glomerata L.) cultivars, Lazuly and Porto, and two summer-active tall fescue (Lolium arundinaceum Schreb., syn. Festuca arundinacea Schreb.) cultivars, Hummer and Quantum II MaxP, were selected to investigate the effects of waterlogging on root growth and morphological change. Cultivars were subjected to four periods of waterlogging treatments (7, 14, 21 and 28 days), while comparable plants were kept under free drained control conditions. The experiment was arranged as a split–split plot design, with waterlogging treatments (waterlogged, control) considered as main plots, time periods (days of waterlogging) as subplots and cultivars as sub-subplots. Plants began to show signs of waterlogging stress 14–21 days after the onset of waterlogging treatments. There were no significant differences in shoot biomass between the waterlogged and control plants of any cultivar. However, waterlogging significantly reduced root dry matter in all cultivars, with greater reduction in cocksfoot (56%) than in tall fescue (38%). Waterlogging also led to increased adventitious root and aerenchyma formation in both species. Cocksfoot cultivars showed a greater increase in adventitious roots, while tall fescue cultivars had a greater proportion of aerenchyma. Both cultivars within each species showed similar responses to waterlogging treatments. However, an extended screening program is needed to identify whether there are varietal differences within species, which could be used to discover genes related to aerenchyma or adventitious root formation (waterlogging tolerance) for use in breeding programs. Full article

As scientists and managers seek to understand fire behavior in conditions that extend beyond the limits of our current empirical models and prior experiences, they will need new tools that foster a more mechanistic understanding of the processes driving fire dynamics and effects. Here we suggest that process-based models are powerful research tools that are useful for investigating a large number of emerging questions in wildland fire sciences. These models can play a particularly important role in advancing our understanding, in part, because they allow their users to evaluate the potential mechanisms and interactions driving fire dynamics and effects from a unique perspective not often available through experimentation alone. For example, process-based models can be used to conduct experiments that would be impossible, too risky, or costly to do in the physical world. They can also contribute to the discovery process by inspiring new experiments, informing measurement strategies, and assisting in the interpretation of physical observations. Ultimately, a synergistic approach where simulations are continuously compared to experimental data, and where experiments are guided by the simulations will profoundly impact the quality and rate of progress towards solving emerging problems in wildland fire sciences. Full article

This article summarizes a version of the “mourning religion” thesis—derived from the work of Peter Homans and further developed and advanced by William Parsons, Diane Jonte-Pace, and Susan Henking—and then demonstrates how this thesis can shed light on the Park51 controversy. We argue that the Park51 controversy represents a case of incomplete cultural mourning of an aspect of American civil religion that manifests itself in melancholic rage by means of protests, threats to burn the Qur’an (as well as actual burnings of the Qur’an), and vandalism of mosques around the United States. We explore various losses—military, economic, and symbolic—and note that these losses remain ambiguous, therefore preventing closure and productive mourning. The fact that a permanent memorial still has not been built at Ground Zero reflects, and perhaps exacerbates, this incomplete cultural mourning. Also, the fact that Freedom Tower, the building to replace the Twin Towers, is to be 1776 feet tall reflects that the losses related to 9/11 are connected to American civil religion, as 1776 is a sacred year in American history. Setting aside the ethics and the politics related to this controversy, we attempt here to understand this controversy from a psychoanalytic perspective. Full article